Ferroptosis as a new tool for tumor suppression through lipid peroxidation
Abstract As a newly defined type of programmed cell death, ferroptosis is considered a potent weapon against tumors due to its distinct mechanism from other types of programmed cell death. Ferroptosis is triggered by the uncontrolled accumulation of hydroperoxyl polyunsaturated fatty acid-containing...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07180-8 |
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| _version_ | 1850196341635940352 |
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| author | Xin Yang Yanqing Liu Zhe Wang Ying Jin Wei Gu |
| author_facet | Xin Yang Yanqing Liu Zhe Wang Ying Jin Wei Gu |
| author_sort | Xin Yang |
| collection | DOAJ |
| description | Abstract As a newly defined type of programmed cell death, ferroptosis is considered a potent weapon against tumors due to its distinct mechanism from other types of programmed cell death. Ferroptosis is triggered by the uncontrolled accumulation of hydroperoxyl polyunsaturated fatty acid-containing phospholipids, also called lipid peroxidation. The lipid peroxidation, generated through enzymatic and non-enzymatic mechanisms, drives changes in cell morphology and the destruction of membrane integrity. Here, we dissect the mechanisms of ferroptosis induced enzymatically or non-enzymatically, summarize the major metabolism pathways in modulating lipid peroxidation, and provide insights into the relationship between ferroptosis and tumor suppression. In this review, we discuss the recent advances of ferroptosis in tumor microenvironments and the prospect of potential therapeutic application. |
| format | Article |
| id | doaj-art-4a6e6d6044c244a194367e40baf8a982 |
| institution | OA Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-4a6e6d6044c244a194367e40baf8a9822025-08-20T02:13:28ZengNature PortfolioCommunications Biology2399-36422024-11-017111210.1038/s42003-024-07180-8Ferroptosis as a new tool for tumor suppression through lipid peroxidationXin Yang0Yanqing Liu1Zhe Wang2Ying Jin3Wei Gu4Suzhou Ninth Hospital Affiliated to Soochow University, The Institutes of Biology and Medical Sciences, Suzhou Medical College, Soochow UniversityInstitute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia UniversityInstitute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia UniversitySuzhou Ninth Hospital Affiliated to Soochow University, Suzhou Ninth People’s Hospital, Suzhou Medical College, Soochow UniversityInstitute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia UniversityAbstract As a newly defined type of programmed cell death, ferroptosis is considered a potent weapon against tumors due to its distinct mechanism from other types of programmed cell death. Ferroptosis is triggered by the uncontrolled accumulation of hydroperoxyl polyunsaturated fatty acid-containing phospholipids, also called lipid peroxidation. The lipid peroxidation, generated through enzymatic and non-enzymatic mechanisms, drives changes in cell morphology and the destruction of membrane integrity. Here, we dissect the mechanisms of ferroptosis induced enzymatically or non-enzymatically, summarize the major metabolism pathways in modulating lipid peroxidation, and provide insights into the relationship between ferroptosis and tumor suppression. In this review, we discuss the recent advances of ferroptosis in tumor microenvironments and the prospect of potential therapeutic application.https://doi.org/10.1038/s42003-024-07180-8 |
| spellingShingle | Xin Yang Yanqing Liu Zhe Wang Ying Jin Wei Gu Ferroptosis as a new tool for tumor suppression through lipid peroxidation Communications Biology |
| title | Ferroptosis as a new tool for tumor suppression through lipid peroxidation |
| title_full | Ferroptosis as a new tool for tumor suppression through lipid peroxidation |
| title_fullStr | Ferroptosis as a new tool for tumor suppression through lipid peroxidation |
| title_full_unstemmed | Ferroptosis as a new tool for tumor suppression through lipid peroxidation |
| title_short | Ferroptosis as a new tool for tumor suppression through lipid peroxidation |
| title_sort | ferroptosis as a new tool for tumor suppression through lipid peroxidation |
| url | https://doi.org/10.1038/s42003-024-07180-8 |
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