Intermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilities
Abstract Background Malaria infection during pregnancy remains a public health concern. Malaria prevention strategies, including chemoprevention, are recommended during pregnancy. This study was conducted to assess the use of intermittent preventive treatment for malaria during pregnancy (IPTp), the...
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2025-08-01
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| Online Access: | https://doi.org/10.1186/s12884-025-07943-z |
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| author | Rebecca Chinyelu Chukwuanukwu George Uchenna Eleje Felix Emeka Menkiti Golibe Christian Ikpeze Chioma Ngozichukwu Mbachu Nnaedozie Paul Obiegbu Confidence Chinaza Ogbomade Hatesin Ifeanyi Anyaegbu Alfred Friday Ehiaghe Dorothy Amauche Ezeagwuna Chidi Callistus Efobi Emmanuel Chukwubuikem Egwuatu Kezie Kenneth Orjinta John Emeka James Chiemezie Mac-Kingsley Agbanu Chinyere Ukamaka Onubuogu Onochie Bruno Ezenwa Chidimma Donatus Okafor Kenechukwu Stanley Onah Titus Osita Chukwuanukwu |
| author_facet | Rebecca Chinyelu Chukwuanukwu George Uchenna Eleje Felix Emeka Menkiti Golibe Christian Ikpeze Chioma Ngozichukwu Mbachu Nnaedozie Paul Obiegbu Confidence Chinaza Ogbomade Hatesin Ifeanyi Anyaegbu Alfred Friday Ehiaghe Dorothy Amauche Ezeagwuna Chidi Callistus Efobi Emmanuel Chukwubuikem Egwuatu Kezie Kenneth Orjinta John Emeka James Chiemezie Mac-Kingsley Agbanu Chinyere Ukamaka Onubuogu Onochie Bruno Ezenwa Chidimma Donatus Okafor Kenechukwu Stanley Onah Titus Osita Chukwuanukwu |
| author_sort | Rebecca Chinyelu Chukwuanukwu |
| collection | DOAJ |
| description | Abstract Background Malaria infection during pregnancy remains a public health concern. Malaria prevention strategies, including chemoprevention, are recommended during pregnancy. This study was conducted to assess the use of intermittent preventive treatment for malaria during pregnancy (IPTp), the prevalence of malaria, HIV, and hepatitis infections and the occurrence of premature rupture of membranes (PROM) among pregnant women in two healthcare facilities in south-eastern Nigeria. Methods A dual hospital-based cross-sectional study was conducted in two hospitals in Anambra State, Nigeria. Pregnant women who provided informed consent were recruited. Blood samples were collected to test for HIV, malaria, hepatitis B and C virus infections. Results Among the 134 participants enrolled, 8 (5.97%) tested positive for malaria, 5 (3.73%) for HIV, and 6 (4.47%) for hepatitis B; preeclampsia was observed in 5 women (3.73%), and 3 (2.24%) experienced PROM. The use of IPTp was relatively high at 73.9%. Preterm deliveries accounted for 5.2% of the cases. Conclusion A lower prevalence of malaria was observed in this study than in previous reports in the region, likely due to the high implementation of IPTp. These findings emphasize the role of IPTp in reducing malaria among pregnant women and provide useful data on HIV, hepatitis and PROM prevalence in the study population. |
| format | Article |
| id | doaj-art-4a6ab899090d4e629c028e46c9c21d6c |
| institution | DOAJ |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
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| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-4a6ab899090d4e629c028e46c9c21d6c2025-08-20T03:06:29ZengBMCBMC Pregnancy and Childbirth1471-23932025-08-012511810.1186/s12884-025-07943-zIntermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilitiesRebecca Chinyelu Chukwuanukwu0George Uchenna Eleje1Felix Emeka Menkiti2Golibe Christian Ikpeze3Chioma Ngozichukwu Mbachu4Nnaedozie Paul Obiegbu5Confidence Chinaza Ogbomade6Hatesin Ifeanyi Anyaegbu7Alfred Friday Ehiaghe8Dorothy Amauche Ezeagwuna9Chidi Callistus Efobi10Emmanuel Chukwubuikem Egwuatu11Kezie Kenneth Orjinta12John Emeka James13Chiemezie Mac-Kingsley Agbanu14Chinyere Ukamaka Onubuogu15Onochie Bruno Ezenwa16Chidimma Donatus Okafor17Kenechukwu Stanley Onah18Titus Osita Chukwuanukwu19Department of Immunology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe UniversityDepartment of Obstetrics & Gynaecology, Faculty of Medicine, Nnamdi Azikiwe UniversityDepartment of Anatomic Pathology and Forensic Medicine, Nnamdi Azikiwe UniversityDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching HospitalDepartment of Paediatrics, Nnamdi Azikiwe University Teaching Hospital NnewiDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching HospitalDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching HospitalDepartment of Immunology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe UniversityDepartment of Immunology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe UniversityDepartment of Parasitology & Entomology, Faculty of Bioscience, Nnamdi Azikiwe UniversityDepartment of Haematology, Faculty of Medical Laboratory Science, Nnamdi Azikiwe UniversityDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching HospitalDepartment of Human Nutrition and Dietetics, Nnamdi Azikiwe UniversityDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching HospitalDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching HospitalDepartment of Paediatrics, Nnamdi Azikiwe University Teaching Hospital NnewiDepartment of Histopathology, Nnamdi Azikiwe University Teaching HospitalDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching HospitalDepartment of Paediatrics, Nnamdi Azikiwe University Teaching Hospital NnewiSurgery Department, Nnamdi Azikiwe UniversityAbstract Background Malaria infection during pregnancy remains a public health concern. Malaria prevention strategies, including chemoprevention, are recommended during pregnancy. This study was conducted to assess the use of intermittent preventive treatment for malaria during pregnancy (IPTp), the prevalence of malaria, HIV, and hepatitis infections and the occurrence of premature rupture of membranes (PROM) among pregnant women in two healthcare facilities in south-eastern Nigeria. Methods A dual hospital-based cross-sectional study was conducted in two hospitals in Anambra State, Nigeria. Pregnant women who provided informed consent were recruited. Blood samples were collected to test for HIV, malaria, hepatitis B and C virus infections. Results Among the 134 participants enrolled, 8 (5.97%) tested positive for malaria, 5 (3.73%) for HIV, and 6 (4.47%) for hepatitis B; preeclampsia was observed in 5 women (3.73%), and 3 (2.24%) experienced PROM. The use of IPTp was relatively high at 73.9%. Preterm deliveries accounted for 5.2% of the cases. Conclusion A lower prevalence of malaria was observed in this study than in previous reports in the region, likely due to the high implementation of IPTp. These findings emphasize the role of IPTp in reducing malaria among pregnant women and provide useful data on HIV, hepatitis and PROM prevalence in the study population.https://doi.org/10.1186/s12884-025-07943-zMalariaIPTpHIVHepatitisPreeclampsiaPROM |
| spellingShingle | Rebecca Chinyelu Chukwuanukwu George Uchenna Eleje Felix Emeka Menkiti Golibe Christian Ikpeze Chioma Ngozichukwu Mbachu Nnaedozie Paul Obiegbu Confidence Chinaza Ogbomade Hatesin Ifeanyi Anyaegbu Alfred Friday Ehiaghe Dorothy Amauche Ezeagwuna Chidi Callistus Efobi Emmanuel Chukwubuikem Egwuatu Kezie Kenneth Orjinta John Emeka James Chiemezie Mac-Kingsley Agbanu Chinyere Ukamaka Onubuogu Onochie Bruno Ezenwa Chidimma Donatus Okafor Kenechukwu Stanley Onah Titus Osita Chukwuanukwu Intermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilities BMC Pregnancy and Childbirth Malaria IPTp HIV Hepatitis Preeclampsia PROM |
| title | Intermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilities |
| title_full | Intermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilities |
| title_fullStr | Intermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilities |
| title_full_unstemmed | Intermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilities |
| title_short | Intermittent preventive treatment, malaria, HIV, hepatitis and pregnancy outcomes in Nigerian women: a cross-sectional study in two healthcare facilities |
| title_sort | intermittent preventive treatment malaria hiv hepatitis and pregnancy outcomes in nigerian women a cross sectional study in two healthcare facilities |
| topic | Malaria IPTp HIV Hepatitis Preeclampsia PROM |
| url | https://doi.org/10.1186/s12884-025-07943-z |
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