HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS

HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS

Abstract Oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) are key bioenergetics pathways. The machineries for both processes are localized in mitochondria. Secondary OXPHOS defects have been documented in patients with primary FAO deficiencies, and vice versa. However, the underlyin...

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Main Authors: Chaoying Qin, Shasha Gong, Ting Liang, Zhenbo Zhang, Jessie Thomas, Janice Deng, Yaguang Liu, Peiqing Hu, Bi Zhu, Shujie Song, Marisol Fernández Ortiz, Yuji Ikeno, Exing Wang, James Lechleiter, Susan T. Weintraub, Yidong Bai
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
fatty acid oxidation (FAO)
HADHA
mitochondrial respiratory chain
mitochondrial trifunctional protein (MTP)
respiratory complex I
Online Access:https://doi.org/10.1002/advs.202405147
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