Mitigating Post-Spinal Anesthesia Shivering by Exploring Intravenous Ketamine vs. Intravenous Tramadol and Comparison of the Optimal Dose of Ketamine: A Scoping Review of Cohort and Randomized Controlled Trials Studies
Background: Shivering is prevalent in 65% of patients undergoing spinal anesthesia, resulting in adverse outcomes and increased healthcare expenses. Ketamine, an N-methyl-D-aspartate receptor antagonist, and tramadol exhibit analgesic properties, potentially mitigating post-spinal shivering. This s...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2024-12-01
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| Series: | Archives of Anesthesia and Critical Care |
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| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/1081 |
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| author | Siavash Sangi Mehrdad Mesbah Kiaei Maryam Aligholizadeh Alireza Babajani Parisa Akbarpour Maryam Sarkhosh Elnaz Jalalkamali Zahra Karimian |
| author_facet | Siavash Sangi Mehrdad Mesbah Kiaei Maryam Aligholizadeh Alireza Babajani Parisa Akbarpour Maryam Sarkhosh Elnaz Jalalkamali Zahra Karimian |
| author_sort | Siavash Sangi |
| collection | DOAJ |
| description |
Background: Shivering is prevalent in 65% of patients undergoing spinal anesthesia, resulting in adverse outcomes and increased healthcare expenses. Ketamine, an N-methyl-D-aspartate receptor antagonist, and tramadol exhibit analgesic properties, potentially mitigating post-spinal shivering. This scoping review aims to explore the existing literature on the intravenously administered ketamine and tramadol in reducing the incidence of shivering subsequent to spinal anesthesia.
Methods: This scoping review, conducted from April to June 2024, examined studies on intravenous ketamine and tramadol for shivering post-spinal anesthesia. Using MeSH terms, researchers searched Scopus, Web of Science, PubMed, Cochrane, Google Scholar, Iran SID, and Iran ISC. After excluding duplicates and irrelevant studies, six pertinent studies were included.
Results: The search strategy identified 1316 articles, with 1258 remaining after removing 58 duplicates. Title and abstract screening excluded 6 conference papers, 42 systematic reviews, 94 book chapters or animal studies, and 2 theses. A full-text review of 97 studies resulted in excluding 78 unrelated cases, 1 language discrepancy, and 11 without full-text availability. Ultimately, 6 studies (5 randomized controlled trials and 1 prospective cohort) from Iran, Pakistan, India, Egypt, and Ethiopia found ketamine more effective than tramadol in preventing shivering.
Conclusion: Ketamine is more effective than tramadol in preventing post-spinal anesthesia shivering, with fewer adverse effects like nausea, vomiting, and bradycardia. These findings support its use for shivering management. Future research should optimize dosing to reduce hallucinations, explore other side effects, and prioritize diverse study parameters and safety evaluations.
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| format | Article |
| id | doaj-art-4a5e243cc63a4e2c9193971f81632d9b |
| institution | OA Journals |
| issn | 2423-5849 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj-art-4a5e243cc63a4e2c9193971f81632d9b2025-08-20T01:49:08ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492024-12-0111310.18502/aacc.v11i3.18506Mitigating Post-Spinal Anesthesia Shivering by Exploring Intravenous Ketamine vs. Intravenous Tramadol and Comparison of the Optimal Dose of Ketamine: A Scoping Review of Cohort and Randomized Controlled Trials StudiesSiavash Sangi0Mehrdad Mesbah Kiaei1Maryam Aligholizadeh2Alireza Babajani3Parisa Akbarpour4Maryam Sarkhosh5Elnaz Jalalkamali6Zahra Karimian7Anesthesia and Operating Room Department, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Anesthesiology and Pain Medicine, Hasheminejad Kidney Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.Anesthesia and Operating Room Department, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Anesthesia Technology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.Department of Anesthesia Technology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.Department of Anesthesia Technology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.Department of Anesthesia Technology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.Anesthesia and Operating Room Department, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Background: Shivering is prevalent in 65% of patients undergoing spinal anesthesia, resulting in adverse outcomes and increased healthcare expenses. Ketamine, an N-methyl-D-aspartate receptor antagonist, and tramadol exhibit analgesic properties, potentially mitigating post-spinal shivering. This scoping review aims to explore the existing literature on the intravenously administered ketamine and tramadol in reducing the incidence of shivering subsequent to spinal anesthesia. Methods: This scoping review, conducted from April to June 2024, examined studies on intravenous ketamine and tramadol for shivering post-spinal anesthesia. Using MeSH terms, researchers searched Scopus, Web of Science, PubMed, Cochrane, Google Scholar, Iran SID, and Iran ISC. After excluding duplicates and irrelevant studies, six pertinent studies were included. Results: The search strategy identified 1316 articles, with 1258 remaining after removing 58 duplicates. Title and abstract screening excluded 6 conference papers, 42 systematic reviews, 94 book chapters or animal studies, and 2 theses. A full-text review of 97 studies resulted in excluding 78 unrelated cases, 1 language discrepancy, and 11 without full-text availability. Ultimately, 6 studies (5 randomized controlled trials and 1 prospective cohort) from Iran, Pakistan, India, Egypt, and Ethiopia found ketamine more effective than tramadol in preventing shivering. Conclusion: Ketamine is more effective than tramadol in preventing post-spinal anesthesia shivering, with fewer adverse effects like nausea, vomiting, and bradycardia. These findings support its use for shivering management. Future research should optimize dosing to reduce hallucinations, explore other side effects, and prioritize diverse study parameters and safety evaluations. https://aacc.tums.ac.ir/index.php/aacc/article/view/1081ShiveringKetamineTramadolSpinal AnesthesiaScoping Review |
| spellingShingle | Siavash Sangi Mehrdad Mesbah Kiaei Maryam Aligholizadeh Alireza Babajani Parisa Akbarpour Maryam Sarkhosh Elnaz Jalalkamali Zahra Karimian Mitigating Post-Spinal Anesthesia Shivering by Exploring Intravenous Ketamine vs. Intravenous Tramadol and Comparison of the Optimal Dose of Ketamine: A Scoping Review of Cohort and Randomized Controlled Trials Studies Archives of Anesthesia and Critical Care Shivering Ketamine Tramadol Spinal Anesthesia Scoping Review |
| title | Mitigating Post-Spinal Anesthesia Shivering by Exploring Intravenous Ketamine vs. Intravenous Tramadol and Comparison of the Optimal Dose of Ketamine: A Scoping Review of Cohort and Randomized Controlled Trials Studies |
| title_full | Mitigating Post-Spinal Anesthesia Shivering by Exploring Intravenous Ketamine vs. Intravenous Tramadol and Comparison of the Optimal Dose of Ketamine: A Scoping Review of Cohort and Randomized Controlled Trials Studies |
| title_fullStr | Mitigating Post-Spinal Anesthesia Shivering by Exploring Intravenous Ketamine vs. Intravenous Tramadol and Comparison of the Optimal Dose of Ketamine: A Scoping Review of Cohort and Randomized Controlled Trials Studies |
| title_full_unstemmed | Mitigating Post-Spinal Anesthesia Shivering by Exploring Intravenous Ketamine vs. Intravenous Tramadol and Comparison of the Optimal Dose of Ketamine: A Scoping Review of Cohort and Randomized Controlled Trials Studies |
| title_short | Mitigating Post-Spinal Anesthesia Shivering by Exploring Intravenous Ketamine vs. Intravenous Tramadol and Comparison of the Optimal Dose of Ketamine: A Scoping Review of Cohort and Randomized Controlled Trials Studies |
| title_sort | mitigating post spinal anesthesia shivering by exploring intravenous ketamine vs intravenous tramadol and comparison of the optimal dose of ketamine a scoping review of cohort and randomized controlled trials studies |
| topic | Shivering Ketamine Tramadol Spinal Anesthesia Scoping Review |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/1081 |
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