Gamma radiation in association with moderate training reduce the effects of asthma in mice
Ionizing radiation has been used for the treatment of various diseases for over a century, including chronic inflammatory diseases and cancer. The relationship between radiation and asthma are contradictory; while some authors associate radiation exposure with the development of the disease, others...
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| Format: | Article |
| Language: | English |
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2022-09-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2068 |
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| author | Nayara Alves Severo Cilene Souza Barreto Maria de Lourdes Meirelles Noviello João Aguiar Nogueira Batista Rosiane Resende Leite Arno Heeren de Oliveria |
| author_facet | Nayara Alves Severo Cilene Souza Barreto Maria de Lourdes Meirelles Noviello João Aguiar Nogueira Batista Rosiane Resende Leite Arno Heeren de Oliveria |
| author_sort | Nayara Alves Severo |
| collection | DOAJ |
| description | Ionizing radiation has been used for the treatment of various diseases for over a century, including chronic inflammatory diseases and cancer. The relationship between radiation and asthma are contradictory; while some authors associate radiation exposure with the development of the disease, others report an attenuation of asthma in response to radiation. Asthma is a chronic inflammatory disease and represents a worldwide public health problem with a high number of deaths. In the present study, we have conducted an investigation of the effects of radiation with 10 doses of 0.5Gy of Co60 and/or moderate lung training of mice with ovalbumin-induced asthma. For this purpose, we have compared six experimental groups of mice: 1-Saline (non-irradiated, sedentary and saline); 2- IR (irradiated and sedentary); 3- OVA (non-irradiated, sedentary and asthma); 4- OVA+IR (irradiated, asthma and sedentary); 5- OVA+IR+MT (irradiated, asthma and moderate training -TM); 6- OVA+MT (asthma and moderate training). The results indicate that radiation and moderate training reduced inflammatory parameters significantly both in BALF cells and in mucus production, thus attenuating the asthma symptoms. |
| format | Article |
| id | doaj-art-4a5db2f1c5364a3c97b309e81eeabd55 |
| institution | Kabale University |
| issn | 2319-0612 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-4a5db2f1c5364a3c97b309e81eeabd552025-08-20T03:27:52ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122022-09-0110310.15392/bjrs.v10i3.20681686Gamma radiation in association with moderate training reduce the effects of asthma in miceNayara Alves Severo0Cilene Souza Barreto1Maria de Lourdes Meirelles Noviello2João Aguiar Nogueira Batista3Rosiane Resende Leite4Arno Heeren de Oliveria5Departamento de Ciências da Saúde - Universidade Estadual de Santa Cruz, BA, BrasilDepartamento de Ciências da Saúde - Universidade Estadual de Santa Cruz, BA, BrasilLaboratório de Patologia e Imunologia – Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, BrasilLaboratório de Patologia e Imunologia – Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, BrasilCentro Federal de Educação Tecnológica de Minas Gerais, MG, BrasilDepartamento de Engenharia Nuclear, Universidade Federal de Minas Gerais ,MG, BrasilIonizing radiation has been used for the treatment of various diseases for over a century, including chronic inflammatory diseases and cancer. The relationship between radiation and asthma are contradictory; while some authors associate radiation exposure with the development of the disease, others report an attenuation of asthma in response to radiation. Asthma is a chronic inflammatory disease and represents a worldwide public health problem with a high number of deaths. In the present study, we have conducted an investigation of the effects of radiation with 10 doses of 0.5Gy of Co60 and/or moderate lung training of mice with ovalbumin-induced asthma. For this purpose, we have compared six experimental groups of mice: 1-Saline (non-irradiated, sedentary and saline); 2- IR (irradiated and sedentary); 3- OVA (non-irradiated, sedentary and asthma); 4- OVA+IR (irradiated, asthma and sedentary); 5- OVA+IR+MT (irradiated, asthma and moderate training -TM); 6- OVA+MT (asthma and moderate training). The results indicate that radiation and moderate training reduced inflammatory parameters significantly both in BALF cells and in mucus production, thus attenuating the asthma symptoms.https://bjrs.org.br/revista/index.php/REVISTA/article/view/2068effects of radiationimmune system, histological analysis |
| spellingShingle | Nayara Alves Severo Cilene Souza Barreto Maria de Lourdes Meirelles Noviello João Aguiar Nogueira Batista Rosiane Resende Leite Arno Heeren de Oliveria Gamma radiation in association with moderate training reduce the effects of asthma in mice Brazilian Journal of Radiation Sciences effects of radiation immune system , histological analysis |
| title | Gamma radiation in association with moderate training reduce the effects of asthma in mice |
| title_full | Gamma radiation in association with moderate training reduce the effects of asthma in mice |
| title_fullStr | Gamma radiation in association with moderate training reduce the effects of asthma in mice |
| title_full_unstemmed | Gamma radiation in association with moderate training reduce the effects of asthma in mice |
| title_short | Gamma radiation in association with moderate training reduce the effects of asthma in mice |
| title_sort | gamma radiation in association with moderate training reduce the effects of asthma in mice |
| topic | effects of radiation immune system , histological analysis |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/2068 |
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