Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy

The prevalence of temporomandibular joint (TMJ) osteoarthritis is 18–85 % of all TMJ dysfunctional conditions. Most patients are elderly, especially women. Today, intra-articular injections are often used for treatment, so it is necessary to study the effectiveness of drug administration on the cour...

Full description

Saved in:
Bibliographic Details
Main Authors: I. A. Shynchukovskyi, O. H. Tereshchuk
Format: Article
Language:English
Published: Zaporizhzhia State Medical and Pharmaceutical University 2024-06-01
Series:Сучасні медичні технології
Subjects:
Online Access:https://medtech.mphu.edu.ua/article/view/300763/297961
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832543007743672320
author I. A. Shynchukovskyi
O. H. Tereshchuk
author_facet I. A. Shynchukovskyi
O. H. Tereshchuk
author_sort I. A. Shynchukovskyi
collection DOAJ
description The prevalence of temporomandibular joint (TMJ) osteoarthritis is 18–85 % of all TMJ dysfunctional conditions. Most patients are elderly, especially women. Today, intra-articular injections are often used for treatment, so it is necessary to study the effectiveness of drug administration on the course of the disease. The number of studies on the effectiveness of certain drugs most commonly used to treat TMJ osteoarthritis is limited, that does not allow correct treatment planning in each individual case. Aim: to evaluate the effectiveness of TMJ osteoarthritis treatment with monotherapy with hyaluronic acid, corticosteroids, and platelet-rich plasma. Materials and methods. We included 90 patients who received intra-articular injections. Patients were randomly divided into 3 groups: group I, which received platelet-rich plasma (PRP, n = 30), group II, which received hyaluronic acid (HA, n = 30), group III, which received corticosteroids (CS, n = 30). To objectively evaluate the effectiveness of TMJ osteoarthritis treatment with monotherapy of hyaluronic acid, corticosteroids and platelet-rich plasma, the following indicators were used: filling in the visual analogue pain scale, maximum mouth opening (mm) and cortical plate density of the articular head of the mandible according to the Hounsfield scale using CBCT. Results. PRP therapy demonstrated the highest efficacy in the form of monotherapy for all study parameters (p < 0.05). The fastest pain reduction was achieved with the use of corticosteroids (p < 0.05). In general, during the treatment period, the reduction of pain according to the visual analogue scale in group I was 85.71 %. In patients of group II (HA) and group III (CS) – by 71.42 %. Maximum mouth opening after treatment in group I increased by 24.32 %, in group II – by 15.79 %, in group III – by 18.92 %. The density of the articular head according to the Hounsfield scale after treatment in group I increased by 12.56 %, in group II – by 6.97 %, in group III – by 4.87 %. Conclusions. All of the studied drugs demonstrated a positive effect on the treatment of TMJ osteoarthritis, but monotherapy with intra-articular PRP injections demonstrated the highest effectiveness according to the studied parameters (p < 0.05).
format Article
id doaj-art-4a59f9ddc3b64553a0975b643a8d0719
institution Kabale University
issn 2072-9367
language English
publishDate 2024-06-01
publisher Zaporizhzhia State Medical and Pharmaceutical University
record_format Article
series Сучасні медичні технології
spelling doaj-art-4a59f9ddc3b64553a0975b643a8d07192025-02-03T11:59:11ZengZaporizhzhia State Medical and Pharmaceutical UniversityСучасні медичні технології2072-93672024-06-0116299104https://doi.org/10.14739/mmt.2024.2.300763Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapyI. A. Shynchukovskyi0https://orcid.org/0000-0002-1571-3877O. H. Tereshchuk1https://orcid.org/0000-0003-2472-1526Bogomolets National Medical University, Kyiv, UkraineBogomolets National Medical University, Kyiv, UkraineThe prevalence of temporomandibular joint (TMJ) osteoarthritis is 18–85 % of all TMJ dysfunctional conditions. Most patients are elderly, especially women. Today, intra-articular injections are often used for treatment, so it is necessary to study the effectiveness of drug administration on the course of the disease. The number of studies on the effectiveness of certain drugs most commonly used to treat TMJ osteoarthritis is limited, that does not allow correct treatment planning in each individual case. Aim: to evaluate the effectiveness of TMJ osteoarthritis treatment with monotherapy with hyaluronic acid, corticosteroids, and platelet-rich plasma. Materials and methods. We included 90 patients who received intra-articular injections. Patients were randomly divided into 3 groups: group I, which received platelet-rich plasma (PRP, n = 30), group II, which received hyaluronic acid (HA, n = 30), group III, which received corticosteroids (CS, n = 30). To objectively evaluate the effectiveness of TMJ osteoarthritis treatment with monotherapy of hyaluronic acid, corticosteroids and platelet-rich plasma, the following indicators were used: filling in the visual analogue pain scale, maximum mouth opening (mm) and cortical plate density of the articular head of the mandible according to the Hounsfield scale using CBCT. Results. PRP therapy demonstrated the highest efficacy in the form of monotherapy for all study parameters (p < 0.05). The fastest pain reduction was achieved with the use of corticosteroids (p < 0.05). In general, during the treatment period, the reduction of pain according to the visual analogue scale in group I was 85.71 %. In patients of group II (HA) and group III (CS) – by 71.42 %. Maximum mouth opening after treatment in group I increased by 24.32 %, in group II – by 15.79 %, in group III – by 18.92 %. The density of the articular head according to the Hounsfield scale after treatment in group I increased by 12.56 %, in group II – by 6.97 %, in group III – by 4.87 %. Conclusions. All of the studied drugs demonstrated a positive effect on the treatment of TMJ osteoarthritis, but monotherapy with intra-articular PRP injections demonstrated the highest effectiveness according to the studied parameters (p < 0.05).https://medtech.mphu.edu.ua/article/view/300763/297961osteoarthritistemporomandibular jointcorticosteroidshyaluronic acidprpintra-articular injections
spellingShingle I. A. Shynchukovskyi
O. H. Tereshchuk
Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy
Сучасні медичні технології
osteoarthritis
temporomandibular joint
corticosteroids
hyaluronic acid
prp
intra-articular injections
title Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy
title_full Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy
title_fullStr Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy
title_full_unstemmed Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy
title_short Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy
title_sort comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids hyaluronic acid and platelet rich plasma mono therapy
topic osteoarthritis
temporomandibular joint
corticosteroids
hyaluronic acid
prp
intra-articular injections
url https://medtech.mphu.edu.ua/article/view/300763/297961
work_keys_str_mv AT iashynchukovskyi comparisonoftheeffectivenessoftemporomandibularjointosteoarthritistreatmentwithcorticosteroidshyaluronicacidandplateletrichplasmamonotherapy
AT ohtereshchuk comparisonoftheeffectivenessoftemporomandibularjointosteoarthritistreatmentwithcorticosteroidshyaluronicacidandplateletrichplasmamonotherapy