In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal Jelly
Trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying m...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3583684 |
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| _version_ | 1850109595559657472 |
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| author | Yi-Fan Chen Kai Wang Yan-Zheng Zhang Yu-Fei Zheng Fu-Liang Hu |
| author_facet | Yi-Fan Chen Kai Wang Yan-Zheng Zhang Yu-Fei Zheng Fu-Liang Hu |
| author_sort | Yi-Fan Chen |
| collection | DOAJ |
| description | Trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying mechanisms by which SEA acts are poorly understood. In the present study, we evaluated and compared the in vitro anti-inflammatory effects of these RJ fatty acids in lipopolysaccharide-stimulated RAW 264.7 macrophages. The results showed that 10-H2DA, 10-HDAA, and SEA had potent, dose-dependent inhibitory effects on the release of the major inflammatory-mediators, nitric oxide, and interleukin-10, and only SEA decreased TNF-α production. Several key inflammatory genes have also been modulated by these RJ fatty acids, with 10-H2DA showing distinct modulating effects as compared to the other two FAs. Furthermore, we found that these three FAs regulated several proteins involved in MAPK and NF-κB signaling pathways. Taken together, these findings provide additional references for using RJ against inflammatory diseases. |
| format | Article |
| id | doaj-art-4a57950d4dfe43b996c940c5a10f95f3 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4a57950d4dfe43b996c940c5a10f95f32025-08-20T02:38:02ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/35836843583684In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal JellyYi-Fan Chen0Kai Wang1Yan-Zheng Zhang2Yu-Fei Zheng3Fu-Liang Hu4College of Animal Sciences, Zhejiang University, Hangzhou 310058, ChinaInstitute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, ChinaCollege of Animal Sciences, Zhejiang University, Hangzhou 310058, ChinaTrans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying mechanisms by which SEA acts are poorly understood. In the present study, we evaluated and compared the in vitro anti-inflammatory effects of these RJ fatty acids in lipopolysaccharide-stimulated RAW 264.7 macrophages. The results showed that 10-H2DA, 10-HDAA, and SEA had potent, dose-dependent inhibitory effects on the release of the major inflammatory-mediators, nitric oxide, and interleukin-10, and only SEA decreased TNF-α production. Several key inflammatory genes have also been modulated by these RJ fatty acids, with 10-H2DA showing distinct modulating effects as compared to the other two FAs. Furthermore, we found that these three FAs regulated several proteins involved in MAPK and NF-κB signaling pathways. Taken together, these findings provide additional references for using RJ against inflammatory diseases.http://dx.doi.org/10.1155/2016/3583684 |
| spellingShingle | Yi-Fan Chen Kai Wang Yan-Zheng Zhang Yu-Fei Zheng Fu-Liang Hu In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal Jelly Mediators of Inflammation |
| title | In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal Jelly |
| title_full | In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal Jelly |
| title_fullStr | In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal Jelly |
| title_full_unstemmed | In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal Jelly |
| title_short | In Vitro Anti-Inflammatory Effects of Three Fatty Acids from Royal Jelly |
| title_sort | in vitro anti inflammatory effects of three fatty acids from royal jelly |
| url | http://dx.doi.org/10.1155/2016/3583684 |
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