Loss of CDC4/FBXW7 in Gastric Carinoma
Background: CDC4/FBXW7, encoding a ubiquitin ligase, maps to 4q32 and has been implicated as a tumor suppressor gene and therapeutic target in many tumor types. Mutations in colonic adenomas, and the frequent losses on 4q described in gastric cancer prompt speculation about the role of CDC4/FBXW7 in...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2010-523 |
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| _version_ | 1850109432836390912 |
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| author | A. N. Milne R. Leguit W. E. Corver F. H. M. Morsink M. Polak W. W. de Leng R. Carvalho G. J. A. Offerhaus |
| author_facet | A. N. Milne R. Leguit W. E. Corver F. H. M. Morsink M. Polak W. W. de Leng R. Carvalho G. J. A. Offerhaus |
| author_sort | A. N. Milne |
| collection | DOAJ |
| description | Background: CDC4/FBXW7, encoding a ubiquitin ligase, maps to 4q32 and has been implicated as a tumor suppressor gene and therapeutic target in many tumor types. Mutations in colonic adenomas, and the frequent losses on 4q described in gastric cancer prompt speculation about the role of CDC4/FBXW7 in gastric carcinogenesis. |
| format | Article |
| id | doaj-art-4a4d3194d2e84ecbbd066886ee4ffd66 |
| institution | OA Journals |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-4a4d3194d2e84ecbbd066886ee4ffd662025-08-20T02:38:05ZengWileyCellular Oncology1570-58701875-86062010-01-01325-634735910.3233/CLO-2010-523Loss of CDC4/FBXW7 in Gastric CarinomaA. N. Milne0R. Leguit1W. E. Corver2F. H. M. Morsink3M. Polak4W. W. de Leng5R. Carvalho6G. J. A. Offerhaus7Department of Pathology, University Medical Centre, Utrecht, The NetherlandsDepartment of Pathology, University Medical Centre, Utrecht, The NetherlandsDepartment of Pathology, Leiden University Medical Centre, Leiden, The NetherlandsDepartment of Pathology, University Medical Centre, Utrecht, The NetherlandsDepartment of Pathology, Academic Medical Centre, Amsterdam, The NetherlandsDepartment of Pathology, University Medical Centre, Utrecht, The NetherlandsZF-Screens BV, Leiden, The NetherlandsDepartment of Pathology, University Medical Centre, Utrecht, The NetherlandsBackground: CDC4/FBXW7, encoding a ubiquitin ligase, maps to 4q32 and has been implicated as a tumor suppressor gene and therapeutic target in many tumor types. Mutations in colonic adenomas, and the frequent losses on 4q described in gastric cancer prompt speculation about the role of CDC4/FBXW7 in gastric carcinogenesis.http://dx.doi.org/10.3233/CLO-2010-523 |
| spellingShingle | A. N. Milne R. Leguit W. E. Corver F. H. M. Morsink M. Polak W. W. de Leng R. Carvalho G. J. A. Offerhaus Loss of CDC4/FBXW7 in Gastric Carinoma Cellular Oncology |
| title | Loss of CDC4/FBXW7 in Gastric Carinoma |
| title_full | Loss of CDC4/FBXW7 in Gastric Carinoma |
| title_fullStr | Loss of CDC4/FBXW7 in Gastric Carinoma |
| title_full_unstemmed | Loss of CDC4/FBXW7 in Gastric Carinoma |
| title_short | Loss of CDC4/FBXW7 in Gastric Carinoma |
| title_sort | loss of cdc4 fbxw7 in gastric carinoma |
| url | http://dx.doi.org/10.3233/CLO-2010-523 |
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