Lang-chuang-ding restores bone homeostasis in systemic lupus erythematosus associated osteoporosis by targeting NF-κB signaling: a network pharmacology and experimental study

Lang-chuang-ding restores bone homeostasis in systemic lupus erythematosus associated osteoporosis by targeting NF-κB signaling: a network pharmacology and experimental study

Systemic lupus erythematosus (SLE) is frequently associated with secondary osteoporosis (OP), substantially compromising patients’ quality of life. Although Lang-chuang-ding (LCD), a traditional Chinese medicine formulation, has demonstrated efficacy in suppressing SLE progression, its therapeutic p...

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Bibliographic Details
Main Authors: Huan Luo, Huiqing Zhou, Shuchao Shen, Lingfeng Zeng, Hongfeng Ruan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Endocrinology
Subjects:
SLE-associated osteoporosis
Lang-chuang-ding
bone homeostasis
inflammatory cytokines
mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1639261/full
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