Prospects for the use of allosteric drugs in real-world clinical practice
While the clinical validity of the use of allosteric regulation is known, scientists are working on the discovery of new methods for the development of allosteric drugs that can modulate the functions of enzymes, depending on the desired therapeutic effect, and have a broader safety profile compared...
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| Format: | Article |
| Language: | Russian |
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Publishing House OKI
2023-12-01
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| Series: | Реальная клиническая практика: данные и доказательства |
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| Online Access: | https://www.myrwd.ru/jour/article/view/49 |
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| author | I. R. Svechkareva A. S. Kolbin |
| author_facet | I. R. Svechkareva A. S. Kolbin |
| author_sort | I. R. Svechkareva |
| collection | DOAJ |
| description | While the clinical validity of the use of allosteric regulation is known, scientists are working on the discovery of new methods for the development of allosteric drugs that can modulate the functions of enzymes, depending on the desired therapeutic effect, and have a broader safety profile compared with alternative drugs. Allosteric modulators are of increasing interest in medicine, some of which are already used in the clinic and some can potentially be used in real-world clinical practice. This article summarizes the current knowledge about allosteric modulation of receptors and their clinical prospects. |
| format | Article |
| id | doaj-art-4a3dd77c29074c54b4bf0a4fdb0f49a7 |
| institution | DOAJ |
| issn | 2782-3784 |
| language | Russian |
| publishDate | 2023-12-01 |
| publisher | Publishing House OKI |
| record_format | Article |
| series | Реальная клиническая практика: данные и доказательства |
| spelling | doaj-art-4a3dd77c29074c54b4bf0a4fdb0f49a72025-08-20T03:19:12ZrusPublishing House OKIРеальная клиническая практика: данные и доказательства2782-37842023-12-0134152110.37489/2782-3784-myrwd-4347Prospects for the use of allosteric drugs in real-world clinical practiceI. R. Svechkareva0A. S. Kolbin1Pavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical University; Saint-Petersburg State UniversityWhile the clinical validity of the use of allosteric regulation is known, scientists are working on the discovery of new methods for the development of allosteric drugs that can modulate the functions of enzymes, depending on the desired therapeutic effect, and have a broader safety profile compared with alternative drugs. Allosteric modulators are of increasing interest in medicine, some of which are already used in the clinic and some can potentially be used in real-world clinical practice. This article summarizes the current knowledge about allosteric modulation of receptors and their clinical prospects.https://www.myrwd.ru/jour/article/view/49allosteric modulationsmall moleculesallosteric drugsreal-world clinical practicepositive allosteric modulatornegative allosteric modulatorpamnam |
| spellingShingle | I. R. Svechkareva A. S. Kolbin Prospects for the use of allosteric drugs in real-world clinical practice Реальная клиническая практика: данные и доказательства allosteric modulation small molecules allosteric drugs real-world clinical practice positive allosteric modulator negative allosteric modulator pam nam |
| title | Prospects for the use of allosteric drugs in real-world clinical practice |
| title_full | Prospects for the use of allosteric drugs in real-world clinical practice |
| title_fullStr | Prospects for the use of allosteric drugs in real-world clinical practice |
| title_full_unstemmed | Prospects for the use of allosteric drugs in real-world clinical practice |
| title_short | Prospects for the use of allosteric drugs in real-world clinical practice |
| title_sort | prospects for the use of allosteric drugs in real world clinical practice |
| topic | allosteric modulation small molecules allosteric drugs real-world clinical practice positive allosteric modulator negative allosteric modulator pam nam |
| url | https://www.myrwd.ru/jour/article/view/49 |
| work_keys_str_mv | AT irsvechkareva prospectsfortheuseofallostericdrugsinrealworldclinicalpractice AT askolbin prospectsfortheuseofallostericdrugsinrealworldclinicalpractice |