A design principle for neuronal firing with up-down oscillation through Na+ dynamics
Summary: Nonrapid eye movement sleep is characterized by high-amplitude and low-frequency electroencephalography signals. These signals are thought to be produced by the synchronized activity of cortical neurons, demonstrating the alternating bursting (up) and resting (down) states. Here, such an ac...
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225001646 |
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| author | Tomohide R. Sato Koji L. Ode Fukuaki L. Kinoshita Hiroki R. Ueda |
| author_facet | Tomohide R. Sato Koji L. Ode Fukuaki L. Kinoshita Hiroki R. Ueda |
| author_sort | Tomohide R. Sato |
| collection | DOAJ |
| description | Summary: Nonrapid eye movement sleep is characterized by high-amplitude and low-frequency electroencephalography signals. These signals are thought to be produced by the synchronized activity of cortical neurons, demonstrating the alternating bursting (up) and resting (down) states. Here, such an activity is referred to as up-down oscillation (UDO). Previously, we discussed the importance of the Ca2+-dependent hyperpolarization pathway in the generation of UDO by simulating neuronal activity based on the Hodgkin-Huxley-type model. We herein focus on intracellular Na+ dynamics. The Na+-centered model indicates that the activation of voltage-gated Na+ channels leads to intracellular Na+ accumulation, which in turn activates Na+-dependent K+ (KNa) channels or Na+/K+ ATPases, resulting in the down state. Activation kinetics of voltage-gated Na+ channels are important in shaping the UDO firing. Therefore, our model demonstrates that voltage-gated Na+ and KNa channels or Na+/K+ ATPases are candidate pathways for UDO induction. |
| format | Article |
| id | doaj-art-4a3d46ccfb624771884f3aaf0850b50c |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-4a3d46ccfb624771884f3aaf0850b50c2025-02-12T05:31:39ZengElsevieriScience2589-00422025-02-01282111904A design principle for neuronal firing with up-down oscillation through Na+ dynamicsTomohide R. Sato0Koji L. Ode1Fukuaki L. Kinoshita2Hiroki R. Ueda3Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Neurology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan; Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan; Department of Systems Biology, Institute of Life Science, Kurume University, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan; Corresponding authorSummary: Nonrapid eye movement sleep is characterized by high-amplitude and low-frequency electroencephalography signals. These signals are thought to be produced by the synchronized activity of cortical neurons, demonstrating the alternating bursting (up) and resting (down) states. Here, such an activity is referred to as up-down oscillation (UDO). Previously, we discussed the importance of the Ca2+-dependent hyperpolarization pathway in the generation of UDO by simulating neuronal activity based on the Hodgkin-Huxley-type model. We herein focus on intracellular Na+ dynamics. The Na+-centered model indicates that the activation of voltage-gated Na+ channels leads to intracellular Na+ accumulation, which in turn activates Na+-dependent K+ (KNa) channels or Na+/K+ ATPases, resulting in the down state. Activation kinetics of voltage-gated Na+ channels are important in shaping the UDO firing. Therefore, our model demonstrates that voltage-gated Na+ and KNa channels or Na+/K+ ATPases are candidate pathways for UDO induction.http://www.sciencedirect.com/science/article/pii/S2589004225001646NeuroscienceCell biologyMathematical biosciences |
| spellingShingle | Tomohide R. Sato Koji L. Ode Fukuaki L. Kinoshita Hiroki R. Ueda A design principle for neuronal firing with up-down oscillation through Na+ dynamics iScience Neuroscience Cell biology Mathematical biosciences |
| title | A design principle for neuronal firing with up-down oscillation through Na+ dynamics |
| title_full | A design principle for neuronal firing with up-down oscillation through Na+ dynamics |
| title_fullStr | A design principle for neuronal firing with up-down oscillation through Na+ dynamics |
| title_full_unstemmed | A design principle for neuronal firing with up-down oscillation through Na+ dynamics |
| title_short | A design principle for neuronal firing with up-down oscillation through Na+ dynamics |
| title_sort | design principle for neuronal firing with up down oscillation through na dynamics |
| topic | Neuroscience Cell biology Mathematical biosciences |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225001646 |
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