Neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder (literature review)
The article discusses the role of inflammatory reactions in the formation of attention deficit hyperactivity disorder (ADHD). Based on a wide and modern material, the mechanisms of development of oxidative stress with the formation of free radicals are considered, which, in turn, initiate a cascade...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2023-04-01
|
| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| Subjects: | |
| Online Access: | https://www.bekhterevreview.com/jour/article/view/802 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849245133416955904 |
|---|---|
| author | R. F. Gasanov I. V. Makarov D. A. Emelina A. S. Avtenuk |
| author_facet | R. F. Gasanov I. V. Makarov D. A. Emelina A. S. Avtenuk |
| author_sort | R. F. Gasanov |
| collection | DOAJ |
| description | The article discusses the role of inflammatory reactions in the formation of attention deficit hyperactivity disorder (ADHD). Based on a wide and modern material, the mechanisms of development of oxidative stress with the formation of free radicals are considered, which, in turn, initiate a cascade of inflammatory reactions. Inflammation factors are analyzed in detail, biomarkers of neuroinflammation are distinguished and their role in changing the neurotransmitter balance is revealed. Biomarkers of neuroinflammation isolated from patients with ADHD give conflicting results in some particular issues, which certainly require clarification. But in general, it is found that increased inflammation in the early stages of brain development seems to be associated with the ADHD phenotype. ADHD is commonly believed to be a hereditary disease; therefore, it can be expected that patients have polymorphisms of genes associated with inflammation, which is illustrated in a wide range of material. In addition, the problems of inducing neuroinflammation with traditional drugs for the treatment of ADHD: methylphenidate and atomoxetine are considered. The prospects of developing algorithms for the diagnosis and treatment of attention deficit hyperactivity disorder are noted. |
| format | Article |
| id | doaj-art-4a3b5b32b788475db0fc840c0a0ea8a5 |
| institution | Kabale University |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2023-04-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-4a3b5b32b788475db0fc840c0a0ea8a52025-08-20T03:58:55ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2023-04-0157182210.31363/2313-7053-2023-699483Neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder (literature review)R. F. Gasanov0I. V. Makarov1D. A. Emelina2A. S. Avtenuk3V.M. Bekhterev National medical research center for psychiatry and neurologyV.M. Bekhterev National medical research center for psychiatry and neurology; North-Western State Medical University named after I.I. MechnikovV.M. Bekhterev National medical research center for psychiatry and neurologyV.M. Bekhterev National medical research center for psychiatry and neurologyThe article discusses the role of inflammatory reactions in the formation of attention deficit hyperactivity disorder (ADHD). Based on a wide and modern material, the mechanisms of development of oxidative stress with the formation of free radicals are considered, which, in turn, initiate a cascade of inflammatory reactions. Inflammation factors are analyzed in detail, biomarkers of neuroinflammation are distinguished and their role in changing the neurotransmitter balance is revealed. Biomarkers of neuroinflammation isolated from patients with ADHD give conflicting results in some particular issues, which certainly require clarification. But in general, it is found that increased inflammation in the early stages of brain development seems to be associated with the ADHD phenotype. ADHD is commonly believed to be a hereditary disease; therefore, it can be expected that patients have polymorphisms of genes associated with inflammation, which is illustrated in a wide range of material. In addition, the problems of inducing neuroinflammation with traditional drugs for the treatment of ADHD: methylphenidate and atomoxetine are considered. The prospects of developing algorithms for the diagnosis and treatment of attention deficit hyperactivity disorder are noted.https://www.bekhterevreview.com/jour/article/view/802neuroinflammationattention deficit hyperactivity disorderoxidative stressneurotransmittersinterleukins |
| spellingShingle | R. F. Gasanov I. V. Makarov D. A. Emelina A. S. Avtenuk Neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder (literature review) Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева neuroinflammation attention deficit hyperactivity disorder oxidative stress neurotransmitters interleukins |
| title | Neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder (literature review) |
| title_full | Neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder (literature review) |
| title_fullStr | Neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder (literature review) |
| title_full_unstemmed | Neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder (literature review) |
| title_short | Neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder (literature review) |
| title_sort | neuroinflammation and its role in the pathogenesis of attention deficit hyperactivity disorder literature review |
| topic | neuroinflammation attention deficit hyperactivity disorder oxidative stress neurotransmitters interleukins |
| url | https://www.bekhterevreview.com/jour/article/view/802 |
| work_keys_str_mv | AT rfgasanov neuroinflammationanditsroleinthepathogenesisofattentiondeficithyperactivitydisorderliteraturereview AT ivmakarov neuroinflammationanditsroleinthepathogenesisofattentiondeficithyperactivitydisorderliteraturereview AT daemelina neuroinflammationanditsroleinthepathogenesisofattentiondeficithyperactivitydisorderliteraturereview AT asavtenuk neuroinflammationanditsroleinthepathogenesisofattentiondeficithyperactivitydisorderliteraturereview |