Toll-like receptor-mediated immune imbalance in asthma: controversies, breakthroughs, and future directions

Toll-like receptor-mediated immune imbalance in asthma: controversies, breakthroughs, and future directions

As a chronic inflammatory illness of the respiratory system, asthma occurs due to various factors and is characterized by a T helper 2 (Th2)-skewed immune response, airway hyperresponsiveness, and reversible airflow obstruction. Toll-like receptors (TLRs) perform a “double-edged sword” function in a...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xinyi Xu, Ruihan Yu, Zhuoqun Yang, Chenyu Li, Huabao Xiong, Chunxia Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Immunology
Subjects:	toll-like receptors toll-like receptors signaling asthma immune cells inflammation cytokines
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605185/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Toll‐like receptors in mammalian sperm
by: Takashi Umehara, et al.
Published: (2025-01-01)

Role of Toll-like Receptors Nine and Ten Polymorphisms in Childhood Bronchial Asthma Control and Their Relation to Cardiac Function
by: Rehab Ahmed Rabie, et al.
Published: (2025-03-01)

Toll‐like receptors in pathogenesis of neurodegenerative diseases and their therapeutic potential
by: Yosef Tsegaye Dabi, et al.
Published: (2023-04-01)

Modulation of the Toll-like Receptor Pathway in Ovine Endometria During Early Pregnancy
by: Guoao Yu, et al.
Published: (2025-03-01)

Evaluation of toll-like receptors 2 and 4 polymorphism and intestinal microbiota in children with food allergies
by: Mehmet Kılıç, et al.
Published: (2023-10-01)

Toll-like receptor agonists as cancer vaccine adjuvants
by: Donghwan Jeon, et al.
Published: (2024-12-01)

CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS
by: V. A. Lazanovich, et al.
Published: (2015-06-01)

Expression of Toll-like receptor (TLR) 2 and TLR4 in the livers of mice infected by Clonorchis sinensis
by: Chao Yan, et al.
Published: (2015-10-01)

Toll-like Receptor Expression Patterns in the Female Reproductive Tract of Sheep
by: Zhibo Wang, et al.
Published: (2025-06-01)

Metabolic Reprogramming in Toll-like Receptor-Mediated Platelet Activation
by: Lih T. Cheah, et al.
Published: (2025-06-01)

MECHANISMS OF ANTIINFECTIOUS FUNCTIONS OF INNATE IMMUNITY: ROLE OF TOLL-LIKE RECEPTORS
by: S. I. Suskov, et al.
Published: (2012-05-01)

Polymorphism of genes of Toll-like receptors as a potential factor of predisposition to tuberculosis
by: E. S. Bogodukhovа, et al.
Published: (2018-10-01)

Extracellular microRNAs initiate immunostimulation via activating toll-like receptor signaling pathways
by: Hongwei Liang, et al.
Published: (2019-02-01)

Toll-like Receptors in Immuno-Metabolic Regulation of Emotion and Memory
by: Carla Crespo-Quiles, et al.
Published: (2025-06-01)

Association of Toll-like Receptor 4 (TLR4) Gene Polymorphism with Multiple Sclerosis (MS) in Iranian Patients
by: Abdolreza Sotoodeh Jahromi, et al.
Published: (2024-01-01)

Impaired interferon‐α expression in plasmacytoid dendritic cells in asthma
by: Ting‐Yu Lin, et al.
Published: (2021-03-01)

Involvement of nucleic acid-sensing toll-like receptors in human diseases and their controlling mechanisms
by: You-Sheng Lin, et al.
Published: (2025-06-01)

The impact of Toll-like receptors on the immune system functioning and on the immunopathogenesis of chronic hepatitis C: a modern view (literature review)
by: L. M. Syzova, et al.
Published: (2020-04-01)

Immunomodulatory responses of toll like receptors against 2019nCoV
by: Amany Sayed Maghraby
Published: (2021-06-01)

The role of Toll-like receptors-4 in the pathogenesis of development of anemia of inflammation in young children
by: H. O. Lezhenko, et al.
Published: (2020-06-01)

Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway
by: Huiqi Yuan, et al.
Published: (2025-02-01)

Dual Role of Host Toll-Like Receptor 3 in Parasitic Diseases
by: Yixin Yang, et al.
Published: (2025-07-01)

Innate Immunity Toll‐Like Triad TLR6‐1‐10 and Its Diversity in Distinct Horse Breeds
by: Karla Stejskalova, et al.
Published: (2025-03-01)

Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications
by: Ahmad Vafaeian, et al.
Published: (2025-02-01)

Research progress of Toll-like receptors in calcified aortic valve disease
by: REN Yiming, et al.
Published: (2024-02-01)

RNAi-mediated suppression of toll-like receptor NlToll1 enhances Nilaparvata lugens susceptibility to entomopathogenic fungal infection
by: Zhu-Long Shao, et al.
Published: (2025-06-01)

Expression of the Toll-like receptors 2 gene as a genetic determinant of the formation of newborns multiple organ failure syndrome
by: Dmytro A Shkurupii
Published: (2019-08-01)

From defense to offense: Modulating toll-like receptors to combat arbovirus infections
by: Rafidah Lani, et al.
Published: (2024-12-01)

Role of Toll-like receptors polymorphisms in the development of extremely severe COVID-19
by: Lyudmila A. Ashchina, et al.
Published: (2025-04-01)

ROLE OF POLYMORPHISMS OF TOLL-LIKE RECEPTORS SIGNALING PATHWAY GENES IN THE DEVELOPMENT OF HEMATOLOGICAL MALIGNANCIES
by: E. L. Nazarova, et al.
Published: (2017-09-01)

The levels of visfatin and toll-like receptors in arterial hypertension and type 2 diabetes mellitus
by: N. Pokrovska, et al.
Published: (2024-04-01)

Hydroxychloroquine in rheumatic autoimmune disorders and beyond
by: Eliise Laura Nirk, et al.
Published: (2020-07-01)

Endosomal Toll-Like Receptors (TLRs) mediate enhancement of IL-17A production triggered by Epstein-Barr virus (EBV) DNA in mice
by: Marwa Shehab, et al.
Published: (2018-02-01)

Expression of surface and intracellular Toll-like receptors by mature mast cells
by: Justyna Agier, et al.
Published: (2017-01-01)

THE ROLE OF TOLL-LIKE RECEPTORS POLYMORPHISM IN ATHEROSCLEROSIS COMPLICATIONS DEVELOPMENT
by: O. L. Barbarash, et al.
Published: (2015-12-01)

Role of Toll-like receptors in exosome biogenesis and angiogenesis capacity
by: Parisa Hassanpour, et al.
Published: (2024-07-01)

Blood Т-cell subpopulations dynamics in asthma under suspended particulate load <i>in vitro</i>
by: E. V. Kondratyeva, et al.
Published: (2025-07-01)

Sparstolonin B Suppresses Proliferation and Modulates Toll-like Receptor Signaling and Inflammatory Pathways in Human Colorectal Cancer Cells
by: Bürke Çırçırlı, et al.
Published: (2025-02-01)

Innate Immune Response to Powassan Virus Infection: Progress Toward Infection Control
by: Mohammad Enamul Hoque Kayesh, et al.
Published: (2025-07-01)

The role of microbiota and toll-like receptors in polycystic ovary syndrome: regulatory mechanisms of androgen metabolism
by: Xueming Huang, et al.
Published: (2025-06-01)