The effect of resistance training on patients with secondary sarcopenia: a systematic review and meta-analysis
Abstract To analyse the effectiveness of resistance training on secondary sarcopenia, we conducted a meta-analysis to elucidate the effects of resistance training (RT) on muscle strength (handgrip strength [HGS]), muscle mass (Skeletal muscle mass index [SMI]), and physical function (Gait speed [GS]...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-79958-z |
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| author | Fang Cheng Na Li Jinfeng Yang Jinqi Yang Weicheng Yang Jianxin Ran Peijie Sun Yuanpeng Liao |
| author_facet | Fang Cheng Na Li Jinfeng Yang Jinqi Yang Weicheng Yang Jianxin Ran Peijie Sun Yuanpeng Liao |
| author_sort | Fang Cheng |
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| description | Abstract To analyse the effectiveness of resistance training on secondary sarcopenia, we conducted a meta-analysis to elucidate the effects of resistance training (RT) on muscle strength (handgrip strength [HGS]), muscle mass (Skeletal muscle mass index [SMI]), and physical function (Gait speed [GS]) in patients with secondary sarcopenia. All studies published between 2015 and January 2024 on the effects of resistance training on patients with secondary sarcopenia were retrieved from 6 electronic databases: PubMed, Web of Science Core Collection, Embase, the Cochrane Library, the China National Knowledge Infrastructure (CNKI) Core journals and the Wanfang Database. Two researchers independently extracted and evaluated studies that met the inclusion and exclusion criteria. Finally, 12 randomized controlled trials were included. Pooled analyses of baseline data and results were performed using Review Manager 5.3 with standardized mean variance (SMD) and random effects model. The study included 12 randomized controlled trials involving 639 patients (mean age 57.28 ± 2.66 to 79.6 ± 5.4 years). There are five types of complications among the patients: obesity, type 2 diabetes, Alzheimer’s disease, hemodiaysis, and pancreatic cancer. Compared with the control group, RT effectively improved HGS [SMD = 2.47, 95% CI (1.50, 3.43), p < 0.01, I2 = 94%]; SMI [SMD = 0.94, 95% CI (0.52, 1.36), p < 0.01, I2 = 56%]; and GS [SMD = 2.18, 95% CI (-0.01, 4.37), p ≥ 0.05, I2 = 97%]. Further subgroup analysis of the results showed that the intervention effect on grip strength was greater for non-elastic band resistance [SMD = 2.40, 95% CI (1.05, 3.75), p < 0.01, I2 = 94%] than for elastic band resistance (EBRT) [SMD = 1.22, 95% CI (-0.14, 2.58), p < 0.01, I2 = 95%]. The intervention effect of RT on grip strength is more significant in patients with T2D [SMD = 0.59, 95%CI (0.26–0.93, p < 0.01, I2 = 27%] and obesity [SMD = 0.74, 95%CI (0.32–1.15, p < 0.01, I2 = 0%]. For patients with secondary sarcopenia, Resistance training (RT) can effectively enhance muscle strength and muscle mass; however, it does not significantly improve physical function. Different RT intervention methods have different effects on patients, such as elastic band training and non-elastic band training (bounce ball RT; equipment RT, etc.). Different types of complications may influence the effectiveness of RT intervention. |
| format | Article |
| id | doaj-art-4a30d229964e4bfc987300d491c40200 |
| institution | OA Journals |
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| spelling | doaj-art-4a30d229964e4bfc987300d491c402002025-08-20T02:22:20ZengNature PortfolioScientific Reports2045-23222024-11-0114111410.1038/s41598-024-79958-zThe effect of resistance training on patients with secondary sarcopenia: a systematic review and meta-analysisFang Cheng0Na Li1Jinfeng Yang2Jinqi Yang3Weicheng Yang4Jianxin Ran5Peijie Sun6Yuanpeng Liao7Department of Sports Medicine and Health, Chengdu Sport UniversityClinical Research Center for Geriatrics Diseases, West China Hospital, Sichuan UniversityDepartment of Sports Medicine and Health, Chengdu Sport UniversityDepartment of Sports Medicine and Health, Chengdu Sport UniversityDepartment of Sports Medicine and Health, Chengdu Sport UniversityDepartment of Sports Medicine and Health, Chengdu Sport UniversityDepartment of Sports Medicine and Health, Chengdu Sport UniversityDepartment of Sports Medicine and Health, Chengdu Sport UniversityAbstract To analyse the effectiveness of resistance training on secondary sarcopenia, we conducted a meta-analysis to elucidate the effects of resistance training (RT) on muscle strength (handgrip strength [HGS]), muscle mass (Skeletal muscle mass index [SMI]), and physical function (Gait speed [GS]) in patients with secondary sarcopenia. All studies published between 2015 and January 2024 on the effects of resistance training on patients with secondary sarcopenia were retrieved from 6 electronic databases: PubMed, Web of Science Core Collection, Embase, the Cochrane Library, the China National Knowledge Infrastructure (CNKI) Core journals and the Wanfang Database. Two researchers independently extracted and evaluated studies that met the inclusion and exclusion criteria. Finally, 12 randomized controlled trials were included. Pooled analyses of baseline data and results were performed using Review Manager 5.3 with standardized mean variance (SMD) and random effects model. The study included 12 randomized controlled trials involving 639 patients (mean age 57.28 ± 2.66 to 79.6 ± 5.4 years). There are five types of complications among the patients: obesity, type 2 diabetes, Alzheimer’s disease, hemodiaysis, and pancreatic cancer. Compared with the control group, RT effectively improved HGS [SMD = 2.47, 95% CI (1.50, 3.43), p < 0.01, I2 = 94%]; SMI [SMD = 0.94, 95% CI (0.52, 1.36), p < 0.01, I2 = 56%]; and GS [SMD = 2.18, 95% CI (-0.01, 4.37), p ≥ 0.05, I2 = 97%]. Further subgroup analysis of the results showed that the intervention effect on grip strength was greater for non-elastic band resistance [SMD = 2.40, 95% CI (1.05, 3.75), p < 0.01, I2 = 94%] than for elastic band resistance (EBRT) [SMD = 1.22, 95% CI (-0.14, 2.58), p < 0.01, I2 = 95%]. The intervention effect of RT on grip strength is more significant in patients with T2D [SMD = 0.59, 95%CI (0.26–0.93, p < 0.01, I2 = 27%] and obesity [SMD = 0.74, 95%CI (0.32–1.15, p < 0.01, I2 = 0%]. For patients with secondary sarcopenia, Resistance training (RT) can effectively enhance muscle strength and muscle mass; however, it does not significantly improve physical function. Different RT intervention methods have different effects on patients, such as elastic band training and non-elastic band training (bounce ball RT; equipment RT, etc.). Different types of complications may influence the effectiveness of RT intervention.https://doi.org/10.1038/s41598-024-79958-zSecondary sarcopeniaRTMuscle strengthMuscle massPhysical function |
| spellingShingle | Fang Cheng Na Li Jinfeng Yang Jinqi Yang Weicheng Yang Jianxin Ran Peijie Sun Yuanpeng Liao The effect of resistance training on patients with secondary sarcopenia: a systematic review and meta-analysis Scientific Reports Secondary sarcopenia RT Muscle strength Muscle mass Physical function |
| title | The effect of resistance training on patients with secondary sarcopenia: a systematic review and meta-analysis |
| title_full | The effect of resistance training on patients with secondary sarcopenia: a systematic review and meta-analysis |
| title_fullStr | The effect of resistance training on patients with secondary sarcopenia: a systematic review and meta-analysis |
| title_full_unstemmed | The effect of resistance training on patients with secondary sarcopenia: a systematic review and meta-analysis |
| title_short | The effect of resistance training on patients with secondary sarcopenia: a systematic review and meta-analysis |
| title_sort | effect of resistance training on patients with secondary sarcopenia a systematic review and meta analysis |
| topic | Secondary sarcopenia RT Muscle strength Muscle mass Physical function |
| url | https://doi.org/10.1038/s41598-024-79958-z |
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