Natural products targeting ubiquitination to combat kidney fibrosis

Natural products targeting ubiquitination to combat kidney fibrosis

Abstract Background Kidney fibrosis is a crucial component that contributes to end-stage renal disease and is the inevitable last pathological process in many progressive chronic kidney diseases (CKD). Ubiquitination, one of the most refined and widespread reversible post-translational modifications...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lianhua Li, Xinhui Huang, Yao Chen, Jibin Liu, Yuhang Qiao, Wenyu Fan, Peiqing Zhang, Xiaoming Yan, Ming Chen
Format:	Article
Language:	English
Published:	SpringerOpen 2025-01-01
Series:	Future Journal of Pharmaceutical Sciences
Subjects:	Kidney fibrosis Ubiquitination Deubiquitination Natural products Signaling pathway TGF-β1/Smads
Online Access:	https://doi.org/10.1186/s43094-024-00757-4
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis
by: Guliang Yang, et al.
Published: (2021-01-01)

Study on effects and relevant mechanisms of Mudan granules on renal fibrosis in streptozotocin-induced diabetes rats
by: Mushuang Qi, et al.
Published: (2024-12-01)

The role of ubiquitination and deubiquitination in cancer lipid metabolism
by: Yongkang Xu, et al.
Published: (2025-01-01)

Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway
by: Jiangtao Wang, et al.
Published: (2025-01-01)

Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance
by: Wenjing Xue, et al.
Published: (2025-01-01)

UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway
by: Lijie Yang, et al.
Published: (2025-01-01)

In vitro and in vivo studies on bioactive hydroxyapatite-coated magnesium for glaucoma drainage implant
by: Huanhuan Gao, et al.
Published: (2025-01-01)

Recent progress in preventive effect of collagen peptides on photoaging skin and action mechanism
by: Chongyang Li, et al.
Published: (2022-03-01)

Carthamin yellow-loaded glycyrrhetinic acid liposomes alleviate interstitial fibrosis in diabetic nephropathy
by: Yifei Wang, et al.
Published: (2025-12-01)

Screening of Anti-Hair Loss Plant Raw Materials Based on Reverse Network Pharmacology and Experimental Validation
by: Jiajia Xu, et al.
Published: (2025-01-01)

CD109, a master regulator of inflammatory responses
by: Adel Batal, et al.
Published: (2025-02-01)

Cross-talk of renal cells through WNT signal transduction in the development of fibrotic kidneys
by: Yuhong Chen, et al.
Published: (2025-02-01)

miR‐130a‐3p regulated TGF‐β1‐induced epithelial‐mesenchymal transition depends on SMAD4 in EC‐1 cells
by: Xiaokang Tian, et al.
Published: (2019-03-01)

Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies
by: Xingpeng Di, et al.
Published: (2025-01-01)

Study on the role of activation of TGF-β pathway by ASPN in the occurrence and development of keloid and the underlying mechanisms
by: XU Xueyan, et al.
Published: (2025-01-01)

Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML
by: Zhanglin Zhang, et al.
Published: (2025-12-01)

Systemic brain dissemination of glioblastoma requires transdifferentiation into endothelial-like cells via TGF-β-ALK1-Smad1/5 signaling
by: Thomas M.B. Ware, et al.
Published: (2025-02-01)

Deer antler velvet (Cervus elaphus sibiricus) promotes fracture healing via partial BMP2-Smad mediated osteoblast differentiation
by: Ji Hyang Gu, et al.
Published: (2025-01-01)

CUL4-Based Ubiquitin Ligases in Chromatin Regulation: An Evolutionary Perspective
by: Makiko Nakagawa, et al.
Published: (2025-01-01)

High interstitial fluid pressure enhances USP1-dependent KIF11 protein stability to promote hepatocellular carcinoma progression
by: Zhengyi Wu, et al.
Published: (2025-01-01)

Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism
by: Jiefeng Huang, et al.
Published: (2025-03-01)

A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma
by: Xiuyun Chen, et al.
Published: (2025-01-01)

CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting β-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells
by: Ping Meng, et al.
Published: (2024-12-01)

Identification of common and specific fibrosis-related genes in three common chronic kidney diseases
by: Zhangning Fu, et al.
Published: (2024-12-01)

Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression
by: Rui Jin, et al.
Published: (2024-12-01)

Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology
by: Arthur D. Stem, et al.
Published: (2025-02-01)

Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain
by: Chen Y, et al.
Published: (2025-02-01)

Liraglutide alleviates high-fat diet-induced kidney injury in mice by regulating the CaMKKβ/AMPK pathway
by: Yingli Xuan, et al.
Published: (2024-12-01)

Research progress on the antiviral immune regulation of ubiquitin ligase F-box family
by: MENG Xiangbo, LI Tianqi, ZHANG Tong
Published: (2025-01-01)

Exploring the role of ubiquitination modifications in migraine headaches
by: Qian Zhu, et al.
Published: (2025-01-01)

Baicalin: a potential therapeutic agent for acute kidney injury and renal fibrosis
by: Xiaoming Li, et al.
Published: (2025-01-01)

Bisphenol S exposure interrupted human embryonic stem cell derived cardiomyocytes differentiation through ER-NF-κB/ERK signaling pathway
by: Yongru Zhou, et al.
Published: (2025-01-01)

Natural antifibrosis potential of anthocyanin in Ipomoea batatas against Transforming Growth Factor beta Type II receptor by in silico ADMET and molecular docking study
by: Evi Lusiana, et al.
Published: (2025-01-01)

Evaluation of the Diversities in the Inflammatory Responses in Cats With Bacterial and Viral Infections
by: Songul Erhan, et al.
Published: (2024-11-01)

Effects of laparoscopic sleeve gastrectomy on nonalcoholic fatty liver disease and TGF-β signaling pathway
by: Hideki Kumagai, et al.
Published: (2024-02-01)

Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn’s disease by bioinformatics analysis and machine learning
by: Wei Chen, et al.
Published: (2025-01-01)

LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation
by: Litao Liang, et al.
Published: (2025-01-01)

Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response
by: Qian Gou, et al.
Published: (2025-02-01)

Incomplete divisions between sister germline cells require Usp8 function
by: Mathieu, Juliette, et al.
Published: (2024-09-01)

Research Progress on Tumor Treatment Strategies Targeting TGF-β
by: Jian ZHANG, et al.
Published: (2025-01-01)