microRNAs: Emerging players in oral cancers and inflammatory disorders
Association of oral diseases and disorders with altered microRNA profiles is firmly recognized. These evidences support the potential use of microRNAs as therapeutic tools for diagnosis, prognosis, and treatment of various diseases. In this review, we highlight the association of altered microRNA si...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317698379 |
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| _version_ | 1849710963745357824 |
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| author | Varun Kulkarni Juhi Raju Uttamani Afsar Raza Naqvi Salvador Nares |
| author_facet | Varun Kulkarni Juhi Raju Uttamani Afsar Raza Naqvi Salvador Nares |
| author_sort | Varun Kulkarni |
| collection | DOAJ |
| description | Association of oral diseases and disorders with altered microRNA profiles is firmly recognized. These evidences support the potential use of microRNAs as therapeutic tools for diagnosis, prognosis, and treatment of various diseases. In this review, we highlight the association of altered microRNA signatures in oral cancers and oral inflammatory diseases. Advances in our ability to detect microRNAs in human sera and saliva further highlight their clinical value as potential biomarkers. We have discussed key mechanisms underlying microRNA dysregulation in pathological conditions. The use of microRNAs in diagnostics and their potential therapeutic value in the treatment of oral diseases are reviewed. |
| format | Article |
| id | doaj-art-4a250a313bd04494aa0f88a995c79d19 |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-4a250a313bd04494aa0f88a995c79d192025-08-20T03:14:45ZengSAGE PublishingTumor Biology1423-03802017-04-013910.1177/1010428317698379microRNAs: Emerging players in oral cancers and inflammatory disordersVarun Kulkarni0Juhi Raju Uttamani1Afsar Raza Naqvi2Salvador Nares3Department of Periodontics, College of Dentistry, The University of Illinois at Chicago, Chicago, IL, USADepartment of Periodontics, College of Dentistry, The University of Illinois at Chicago, Chicago, IL, USADepartment of Periodontics, College of Dentistry, The University of Illinois at Chicago, Chicago, IL, USADepartment of Periodontics, College of Dentistry, The University of Illinois at Chicago, Chicago, IL, USAAssociation of oral diseases and disorders with altered microRNA profiles is firmly recognized. These evidences support the potential use of microRNAs as therapeutic tools for diagnosis, prognosis, and treatment of various diseases. In this review, we highlight the association of altered microRNA signatures in oral cancers and oral inflammatory diseases. Advances in our ability to detect microRNAs in human sera and saliva further highlight their clinical value as potential biomarkers. We have discussed key mechanisms underlying microRNA dysregulation in pathological conditions. The use of microRNAs in diagnostics and their potential therapeutic value in the treatment of oral diseases are reviewed.https://doi.org/10.1177/1010428317698379 |
| spellingShingle | Varun Kulkarni Juhi Raju Uttamani Afsar Raza Naqvi Salvador Nares microRNAs: Emerging players in oral cancers and inflammatory disorders Tumor Biology |
| title | microRNAs: Emerging players in oral cancers and inflammatory disorders |
| title_full | microRNAs: Emerging players in oral cancers and inflammatory disorders |
| title_fullStr | microRNAs: Emerging players in oral cancers and inflammatory disorders |
| title_full_unstemmed | microRNAs: Emerging players in oral cancers and inflammatory disorders |
| title_short | microRNAs: Emerging players in oral cancers and inflammatory disorders |
| title_sort | micrornas emerging players in oral cancers and inflammatory disorders |
| url | https://doi.org/10.1177/1010428317698379 |
| work_keys_str_mv | AT varunkulkarni micrornasemergingplayersinoralcancersandinflammatorydisorders AT juhirajuuttamani micrornasemergingplayersinoralcancersandinflammatorydisorders AT afsarrazanaqvi micrornasemergingplayersinoralcancersandinflammatorydisorders AT salvadornares micrornasemergingplayersinoralcancersandinflammatorydisorders |