Reprogramming of human urine cells into cardiomyocytes via a small molecule cocktail in xeno-free conditions

Abstract Background Cell therapy, particularly using cardiomyocytes, shows significant promise for treating heart failure. Direct reprogramming of somatic cells into cardiomyocytes using small molecules is advantageous due to its efficiency and cost-effectiveness. Methods Human urine-derived cells (...

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Bibliographic Details
Main Authors: Yu Chen, Aoli Li, Aijie Liu, Wei Zheng, Haishi Fan, Jingwei Zhang, Chenwen Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00963-y
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