Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California
Background. Although it is well known that obesity is a risk factor for gastrointestinal (GI) cancer, it is not well established if obesity can cause earlier GI cancer onset. Methods. A cross-sectional study examining the linked 2004–2008 California Cancer Registry Patient Discharge Database was per...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2018/7014073 |
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| author | Yen-Yi Juo Melinda A. Maggard Gibbons Erik Dutson Anne Y. Lin Jane Yanagawa O. Joe Hines Guido Eibl Yijun Chen |
| author_facet | Yen-Yi Juo Melinda A. Maggard Gibbons Erik Dutson Anne Y. Lin Jane Yanagawa O. Joe Hines Guido Eibl Yijun Chen |
| author_sort | Yen-Yi Juo |
| collection | DOAJ |
| description | Background. Although it is well known that obesity is a risk factor for gastrointestinal (GI) cancer, it is not well established if obesity can cause earlier GI cancer onset. Methods. A cross-sectional study examining the linked 2004–2008 California Cancer Registry Patient Discharge Database was performed to evaluate the association between obesity and onset age among four gastrointestinal cancers, including esophageal, gastric, pancreatic, and colorectal cancers. Regression models were constructed to adjust for other carcinogenic factors. Results. The diagnosis of obesity (BMI > 30) was associated with a reduction in diagnosis age across all four cancer types: 3.25 ± 0.53 years for gastric cancer, 4.56 ± 0.18 years for colorectal cancer, 4.73 ± 0.73 years for esophageal cancer, and 5.35 ± 0.72 for pancreatic cancer. The diagnosis of morbid obesity (BMI > 40) was associated with a more pronounced reduction in the age of diagnosis: 5.48 ± 0.96 years for gastric cancer, 7.75 ± 0.30 years for colorectal cancer, 7.67 ± 1.26 years for esophageal cancer, and 8.19 ± 1.25 years for pancreatic cancer. Both morbid obesity and obesity remained strongly associated with earlier cancer diagnosis for all four cancer types even after adjusting for other available cancer risk factors. Conclusions. The diagnosis of obesity, especially morbid obesity, was associated with a significantly earlier gastrointestinal cancer onset in California. Further research with prospective cohort data may be required to establish the causal relationship between obesity and cancer onset age. |
| format | Article |
| id | doaj-art-4a21c116724d4dabb485a0938b89b154 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-4a21c116724d4dabb485a0938b89b1542025-02-03T06:05:30ZengWileyJournal of Obesity2090-07082090-07162018-01-01201810.1155/2018/70140737014073Obesity Is Associated with Early Onset of Gastrointestinal Cancers in CaliforniaYen-Yi Juo0Melinda A. Maggard Gibbons1Erik Dutson2Anne Y. Lin3Jane Yanagawa4O. Joe Hines5Guido Eibl6Yijun Chen7Center for Advanced Surgical and Interventional Technology (CASIT), University of California, 757 Westwood Plaza, Suite B-792, Los Angeles, CA 90095, USADepartment of Surgery, University of California, Box 956904, 72-251 Center for Health Sciences, Los Angeles, CA 90095, USACenter for Advanced Surgical and Interventional Technology (CASIT), University of California, 757 Westwood Plaza, Suite B-792, Los Angeles, CA 90095, USADepartment of Surgery, University of California, Box 956904, 72-251 Center for Health Sciences, Los Angeles, CA 90095, USADepartment of Surgery, University of California, Box 956904, 72-251 Center for Health Sciences, Los Angeles, CA 90095, USADepartment of Surgery, University of California, Box 956904, 72-251 Center for Health Sciences, Los Angeles, CA 90095, USADepartment of Surgery, University of California, Box 956904, 72-251 Center for Health Sciences, Los Angeles, CA 90095, USADepartment of Surgery, University of California, Box 956904, 72-251 Center for Health Sciences, Los Angeles, CA 90095, USABackground. Although it is well known that obesity is a risk factor for gastrointestinal (GI) cancer, it is not well established if obesity can cause earlier GI cancer onset. Methods. A cross-sectional study examining the linked 2004–2008 California Cancer Registry Patient Discharge Database was performed to evaluate the association between obesity and onset age among four gastrointestinal cancers, including esophageal, gastric, pancreatic, and colorectal cancers. Regression models were constructed to adjust for other carcinogenic factors. Results. The diagnosis of obesity (BMI > 30) was associated with a reduction in diagnosis age across all four cancer types: 3.25 ± 0.53 years for gastric cancer, 4.56 ± 0.18 years for colorectal cancer, 4.73 ± 0.73 years for esophageal cancer, and 5.35 ± 0.72 for pancreatic cancer. The diagnosis of morbid obesity (BMI > 40) was associated with a more pronounced reduction in the age of diagnosis: 5.48 ± 0.96 years for gastric cancer, 7.75 ± 0.30 years for colorectal cancer, 7.67 ± 1.26 years for esophageal cancer, and 8.19 ± 1.25 years for pancreatic cancer. Both morbid obesity and obesity remained strongly associated with earlier cancer diagnosis for all four cancer types even after adjusting for other available cancer risk factors. Conclusions. The diagnosis of obesity, especially morbid obesity, was associated with a significantly earlier gastrointestinal cancer onset in California. Further research with prospective cohort data may be required to establish the causal relationship between obesity and cancer onset age.http://dx.doi.org/10.1155/2018/7014073 |
| spellingShingle | Yen-Yi Juo Melinda A. Maggard Gibbons Erik Dutson Anne Y. Lin Jane Yanagawa O. Joe Hines Guido Eibl Yijun Chen Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California Journal of Obesity |
| title | Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California |
| title_full | Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California |
| title_fullStr | Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California |
| title_full_unstemmed | Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California |
| title_short | Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California |
| title_sort | obesity is associated with early onset of gastrointestinal cancers in california |
| url | http://dx.doi.org/10.1155/2018/7014073 |
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