TSLP: contrasting roles in cancer
Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα. TSLP is predominantly expressed by epithelial cells and keratinocytes...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627235/full |
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| author | Remo Poto Remo Poto Remo Poto Gianni Marone Gianni Marone Gianni Marone Steven F. Ziegler Steven F. Ziegler Steven F. Ziegler Gilda Varricchi Gilda Varricchi Gilda Varricchi |
| author_facet | Remo Poto Remo Poto Remo Poto Gianni Marone Gianni Marone Gianni Marone Steven F. Ziegler Steven F. Ziegler Steven F. Ziegler Gilda Varricchi Gilda Varricchi Gilda Varricchi |
| author_sort | Remo Poto |
| collection | DOAJ |
| description | Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα. TSLP is predominantly expressed by epithelial cells and keratinocytes but can also be produced by several immune cells and some cancers. TSLP activates a plethora of immune cells implicated in inflammation, angiogenesis and tumorigenesis. In addition to its role in barrier immunity, recent studies have a role for TSLP in cancer development. This includes both human hematologic cancers and several solid tumors (largely carcinomas). The role of TSLP in human and experimental cancers has been the focus of several studies, with somewhat contradictory findings. In this Review, we will highlight recent advances in TSLP immunobiology in the context of human and experimental cancers. We will also discuss recent findings demonstrating that an anti-TSLP monoclonal antibody (mAb) can exert a protective effect in a mouse model of colorectal cancer. The recent approval of an anti-TSLP mAb for asthma treatment also emphasizes the urgent need for additional research on the role of TSLP, a Janus cytokine, in tumorigenesis. |
| format | Article |
| id | doaj-art-4a17bad29c874322aaf5192811790301 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-4a17bad29c874322aaf51928117903012025-08-20T03:36:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16272351627235TSLP: contrasting roles in cancerRemo Poto0Remo Poto1Remo Poto2Gianni Marone3Gianni Marone4Gianni Marone5Steven F. Ziegler6Steven F. Ziegler7Steven F. Ziegler8Gilda Varricchi9Gilda Varricchi10Gilda Varricchi11Department of Translational Medical Sciences, University of Naples Federico II, Naples, ItalyIstituti Clinici Scientifici Maugeri-Scientific Institute for Research Hospitalization and Healthcare (IRCCS) Scientific Institute of Telese Terme, Benevento, ItalyWorld Allergy Organization (WAO), Center of Excellence (CoE), Naples, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, ItalyWorld Allergy Organization (WAO), Center of Excellence (CoE), Naples, ItalyCenter for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, ItalyBenaroya Research Institute, Seattle, WA, United StatesDivision of Allergy and Infectious Diseases, University of Washington, Seattle, WA, United StatesDepartment of Immunology, University of Washington, Seattle, WA, United StatesDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, ItalyWorld Allergy Organization (WAO), Center of Excellence (CoE), Naples, ItalyCenter for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, ItalyThymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα. TSLP is predominantly expressed by epithelial cells and keratinocytes but can also be produced by several immune cells and some cancers. TSLP activates a plethora of immune cells implicated in inflammation, angiogenesis and tumorigenesis. In addition to its role in barrier immunity, recent studies have a role for TSLP in cancer development. This includes both human hematologic cancers and several solid tumors (largely carcinomas). The role of TSLP in human and experimental cancers has been the focus of several studies, with somewhat contradictory findings. In this Review, we will highlight recent advances in TSLP immunobiology in the context of human and experimental cancers. We will also discuss recent findings demonstrating that an anti-TSLP monoclonal antibody (mAb) can exert a protective effect in a mouse model of colorectal cancer. The recent approval of an anti-TSLP mAb for asthma treatment also emphasizes the urgent need for additional research on the role of TSLP, a Janus cytokine, in tumorigenesis.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627235/fullalarmincancer immunitycytokineTSLPTSLP isoformstumor microenvironment |
| spellingShingle | Remo Poto Remo Poto Remo Poto Gianni Marone Gianni Marone Gianni Marone Steven F. Ziegler Steven F. Ziegler Steven F. Ziegler Gilda Varricchi Gilda Varricchi Gilda Varricchi TSLP: contrasting roles in cancer Frontiers in Immunology alarmin cancer immunity cytokine TSLP TSLP isoforms tumor microenvironment |
| title | TSLP: contrasting roles in cancer |
| title_full | TSLP: contrasting roles in cancer |
| title_fullStr | TSLP: contrasting roles in cancer |
| title_full_unstemmed | TSLP: contrasting roles in cancer |
| title_short | TSLP: contrasting roles in cancer |
| title_sort | tslp contrasting roles in cancer |
| topic | alarmin cancer immunity cytokine TSLP TSLP isoforms tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627235/full |
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