ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway

ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway

Abstract Osteoporosis (OP) is a common systemic metabolic bone disease characterized by the decrease in bone mass and hyperactivity of osteoclasts. ACT001 is approved as an orphan drug by FDA and has shown multiple protective effects against tissue injury. However, its role in prevention of osteocla...

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Bibliographic Details
Main Authors: Yuan Li, Jin-Yu Yang, Ma-Li Lin, Tian-Zhu Liu, Wen-Na Lu, Ying Yang, Zhong-Cheng Liu, Jian-Heng Li, Guo-Qiang Zhang, Jian-Shuang Guo
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Medicine
Subjects:
ACT001
Osteoporosis
Osteoclastogenesis
NF-κB pathway
NLRP3 inflammasome
Online Access:https://doi.org/10.1186/s10020-025-01189-3
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