Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With Polyangiitis
Epstein-Barr virus (EBV)–associated lymphoproliferative disorders (LPDs) are rare conditions. Immunomodulatory therapies impair T-cell–mediated immune responses to latent EBV-infected memory B cells, promoting their reactivation and leading to the excessive division of infected cells, which can resu...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-12-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0228 |
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| author | Indira Acharya Lanaya Williams Smith Stuart Mitchell Levine Huaibin Mabel Ko Govind Bhagat Christopher J. Haas |
| author_facet | Indira Acharya Lanaya Williams Smith Stuart Mitchell Levine Huaibin Mabel Ko Govind Bhagat Christopher J. Haas |
| author_sort | Indira Acharya |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV)–associated lymphoproliferative disorders (LPDs) are rare conditions. Immunomodulatory therapies impair T-cell–mediated immune responses to latent EBV-infected memory B cells, promoting their reactivation and leading to the excessive division of infected cells, which can result in the development of EBV-associated lymphocyte proliferations. Lymphoproliferative disorders related to immunomodulatory agents are recognized as potential life-threatening complications of prolonged immunomodulator administration. Methotrexate-associated LPDs in rheumatoid arthritis and azathioprine-associated LPDs in inflammatory bowel disease have been reported previously. To our knowledge, we report a unique and possibly the first documented case of a B-cell LPD, specifically an EBV-associated polymorphic LPD, involving the adrenal gland in a patient with granulomatosis with polyangiitis treated with azathioprine. |
| format | Article |
| id | doaj-art-4a0e2957df15493bbb6f4f15c4b2e138 |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-4a0e2957df15493bbb6f4f15c4b2e1382025-08-20T02:12:57ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-12-0131210.7326/aimcc.2024.0228Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With PolyangiitisIndira Acharya0Lanaya Williams Smith1Stuart Mitchell Levine2Huaibin Mabel Ko3Govind Bhagat4Christopher J. Haas51Medstar Health Internal Medicine Residency Program, Baltimore, Maryland2MedStar Good Samaritan Hospital, Baltimore, Maryland2MedStar Good Samaritan Hospital, Baltimore, Maryland3Columbia University, Irving Medical Center, New York, New York3Columbia University, Irving Medical Center, New York, New York1Medstar Health Internal Medicine Residency Program, Baltimore, MarylandEpstein-Barr virus (EBV)–associated lymphoproliferative disorders (LPDs) are rare conditions. Immunomodulatory therapies impair T-cell–mediated immune responses to latent EBV-infected memory B cells, promoting their reactivation and leading to the excessive division of infected cells, which can result in the development of EBV-associated lymphocyte proliferations. Lymphoproliferative disorders related to immunomodulatory agents are recognized as potential life-threatening complications of prolonged immunomodulator administration. Methotrexate-associated LPDs in rheumatoid arthritis and azathioprine-associated LPDs in inflammatory bowel disease have been reported previously. To our knowledge, we report a unique and possibly the first documented case of a B-cell LPD, specifically an EBV-associated polymorphic LPD, involving the adrenal gland in a patient with granulomatosis with polyangiitis treated with azathioprine.https://www.acpjournals.org/doi/10.7326/aimcc.2024.0228 |
| spellingShingle | Indira Acharya Lanaya Williams Smith Stuart Mitchell Levine Huaibin Mabel Ko Govind Bhagat Christopher J. Haas Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With Polyangiitis Annals of Internal Medicine: Clinical Cases |
| title | Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With Polyangiitis |
| title_full | Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With Polyangiitis |
| title_fullStr | Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With Polyangiitis |
| title_full_unstemmed | Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With Polyangiitis |
| title_short | Epstein-Barr Virus–Associated B-Cell Lymphoproliferative Disorder Involving the Adrenal Gland in Granulomatosis With Polyangiitis |
| title_sort | epstein barr virus associated b cell lymphoproliferative disorder involving the adrenal gland in granulomatosis with polyangiitis |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0228 |
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