Evaluation of the Immune Effect of a Trivalent Fowl Adenovirus Inactivated Vaccine Against FAdV-4/8a/8b
Fowl adenovirus can cause various diseases such as hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH), which leads to huge economic losses for China’s poultry industry. In recent years, the prevalence of FAdV-4, FAdV-8a, and FAdV-8b has been on the rise. In this study, a tr...
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MDPI AG
2025-06-01
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| author | Yulan Jiao Qianhui Zhao Yulong Zhao Yingjie Li Sumin Pan Yinming Li Yuntao Liu Wanyu Shi |
| author_facet | Yulan Jiao Qianhui Zhao Yulong Zhao Yingjie Li Sumin Pan Yinming Li Yuntao Liu Wanyu Shi |
| author_sort | Yulan Jiao |
| collection | DOAJ |
| description | Fowl adenovirus can cause various diseases such as hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH), which leads to huge economic losses for China’s poultry industry. In recent years, the prevalence of FAdV-4, FAdV-8a, and FAdV-8b has been on the rise. In this study, a trivalent fowl adenovirus inactivated vaccine against FAdV-4/8a/8b was generated and the immune effect was evaluated. The results showed that chickens immunized with the trivalent vaccine could effectively resist the challenge of virulent strains of FAdV-4, FAdV-8a, and FAdV-8b. All chickens in the immunized groups survived after virus injection, gained weight normally, and the lesions in tissues and organs (liver, spleen, kidney, etc.) were significantly decreased compared with the control group. The viral load in the liver of the immunized group was significantly lower than that of the challenge control group five days after the challenge (<i>p</i> < 0.01), and the cloacal excretion was significantly lower than that of the non-immune control group (<i>p</i> < 0.01). Moreover, until 16 weeks after immunization, the neutralizing antibody level against FAdV-4, FAdV-8a, and FAdV-8b remained above 8.27 log2. As a result, the trivalent vaccine generated in our study was an attractive candidate to prevent and reduce the spread of HHS and IBH in China’s poultry industry. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Veterinary Sciences |
| spelling | doaj-art-4a074f2d99de4ba1bea81f2bc26078732025-08-20T03:32:31ZengMDPI AGVeterinary Sciences2306-73812025-06-0112654910.3390/vetsci12060549Evaluation of the Immune Effect of a Trivalent Fowl Adenovirus Inactivated Vaccine Against FAdV-4/8a/8bYulan Jiao0Qianhui Zhao1Yulong Zhao2Yingjie Li3Sumin Pan4Yinming Li5Yuntao Liu6Wanyu Shi7College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, ChinaCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, ChinaRingpu (Baoding) Biological Pharmaceutical Co., Ltd., Baoding 071000, ChinaVeterinary Drug and Feed Work Station of Hebei Province, Shijiazhuang 050011, ChinaCollege of Animal Science and Technology, Hebei Normal University of Science and Technology (HNUST), Qinhuangdao 066004, ChinaCollege of Foreign Language, Hebei Agricultural University, Baoding 071001, ChinaRingpu (Baoding) Biological Pharmaceutical Co., Ltd., Baoding 071000, ChinaCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, ChinaFowl adenovirus can cause various diseases such as hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH), which leads to huge economic losses for China’s poultry industry. In recent years, the prevalence of FAdV-4, FAdV-8a, and FAdV-8b has been on the rise. In this study, a trivalent fowl adenovirus inactivated vaccine against FAdV-4/8a/8b was generated and the immune effect was evaluated. The results showed that chickens immunized with the trivalent vaccine could effectively resist the challenge of virulent strains of FAdV-4, FAdV-8a, and FAdV-8b. All chickens in the immunized groups survived after virus injection, gained weight normally, and the lesions in tissues and organs (liver, spleen, kidney, etc.) were significantly decreased compared with the control group. The viral load in the liver of the immunized group was significantly lower than that of the challenge control group five days after the challenge (<i>p</i> < 0.01), and the cloacal excretion was significantly lower than that of the non-immune control group (<i>p</i> < 0.01). Moreover, until 16 weeks after immunization, the neutralizing antibody level against FAdV-4, FAdV-8a, and FAdV-8b remained above 8.27 log2. As a result, the trivalent vaccine generated in our study was an attractive candidate to prevent and reduce the spread of HHS and IBH in China’s poultry industry.https://www.mdpi.com/2306-7381/12/6/549fowl adenovirusinactivated vaccineimmune protectionneutralizing antibodyHHSIBH |
| spellingShingle | Yulan Jiao Qianhui Zhao Yulong Zhao Yingjie Li Sumin Pan Yinming Li Yuntao Liu Wanyu Shi Evaluation of the Immune Effect of a Trivalent Fowl Adenovirus Inactivated Vaccine Against FAdV-4/8a/8b Veterinary Sciences fowl adenovirus inactivated vaccine immune protection neutralizing antibody HHS IBH |
| title | Evaluation of the Immune Effect of a Trivalent Fowl Adenovirus Inactivated Vaccine Against FAdV-4/8a/8b |
| title_full | Evaluation of the Immune Effect of a Trivalent Fowl Adenovirus Inactivated Vaccine Against FAdV-4/8a/8b |
| title_fullStr | Evaluation of the Immune Effect of a Trivalent Fowl Adenovirus Inactivated Vaccine Against FAdV-4/8a/8b |
| title_full_unstemmed | Evaluation of the Immune Effect of a Trivalent Fowl Adenovirus Inactivated Vaccine Against FAdV-4/8a/8b |
| title_short | Evaluation of the Immune Effect of a Trivalent Fowl Adenovirus Inactivated Vaccine Against FAdV-4/8a/8b |
| title_sort | evaluation of the immune effect of a trivalent fowl adenovirus inactivated vaccine against fadv 4 8a 8b |
| topic | fowl adenovirus inactivated vaccine immune protection neutralizing antibody HHS IBH |
| url | https://www.mdpi.com/2306-7381/12/6/549 |
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