L-shaped association between fasting blood glucose and urea in a non-diabetic population
BackgroundThe relationship between fasting blood glucose and urea in non-diabetic individuals is still unclear. This study aimed to evaluate the association between fasting blood glucose and urea in a non-diabetic population.MethodsData from a cohort of non-diabetic individuals were collected from t...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1504855/full |
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| author | Chenguang Wu Zhenyan Xu Zhenyan Xu Xin Chen Hualong Liu Yuliang Chen Jiaxing Huang Teng Lu Zixi Huang |
| author_facet | Chenguang Wu Zhenyan Xu Zhenyan Xu Xin Chen Hualong Liu Yuliang Chen Jiaxing Huang Teng Lu Zixi Huang |
| author_sort | Chenguang Wu |
| collection | DOAJ |
| description | BackgroundThe relationship between fasting blood glucose and urea in non-diabetic individuals is still unclear. This study aimed to evaluate the association between fasting blood glucose and urea in a non-diabetic population.MethodsData from a cohort of non-diabetic individuals were collected from the 2009 China Health and Nutrition Survey dataset. We performed smooth curve and two piecewise linear regression analyses to assess the association between fasting blood glucose and urea in this non-diabetic population.ResultsData from a total of 7,596 adult participants without diabetes were included in this study; the mean age of the participants was 50.2 years, and 46.4% were male. There was an L-shaped relationship between fasting blood glucose and urea, and the inflection point of fasting blood glucose was 4.6 mmol/L. After adjusting for potential confounders, we found a negative correlation between fasting blood glucose and urea up to the inflection point (β = −0.3, 95% CI −0.5 to −0.2, P < 0.001), but beyond the inflection point, this relationship disappeared (β = 0.0, 95% CI −0.1 to 0.1 P = 0.848). In the group with lower fasting blood glucose (fasting blood glucose <4.6 mmol/L), smoking (interaction P = 0.037) and alcohol consumption (interaction P = 0.001) influenced the relationship between fasting blood glucose and urea.ConclusionsThe results suggest that lower fasting blood glucose was associated with higher urea in non-diabetic individuals with fasting blood glucose <4.6 mmol/L, revealing an L-shaped association between fasting blood glucose and urea. |
| format | Article |
| id | doaj-art-4a04fff0fd604d5d8a5104e79dd71991 |
| institution | DOAJ |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-4a04fff0fd604d5d8a5104e79dd719912025-08-20T02:41:36ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-03-011210.3389/fnut.2025.15048551504855L-shaped association between fasting blood glucose and urea in a non-diabetic populationChenguang Wu0Zhenyan Xu1Zhenyan Xu2Xin Chen3Hualong Liu4Yuliang Chen5Jiaxing Huang6Teng Lu7Zixi Huang8Department of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Health Care, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of General Practice, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of Cardiovascular Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaDepartment of General Practice, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaBackgroundThe relationship between fasting blood glucose and urea in non-diabetic individuals is still unclear. This study aimed to evaluate the association between fasting blood glucose and urea in a non-diabetic population.MethodsData from a cohort of non-diabetic individuals were collected from the 2009 China Health and Nutrition Survey dataset. We performed smooth curve and two piecewise linear regression analyses to assess the association between fasting blood glucose and urea in this non-diabetic population.ResultsData from a total of 7,596 adult participants without diabetes were included in this study; the mean age of the participants was 50.2 years, and 46.4% were male. There was an L-shaped relationship between fasting blood glucose and urea, and the inflection point of fasting blood glucose was 4.6 mmol/L. After adjusting for potential confounders, we found a negative correlation between fasting blood glucose and urea up to the inflection point (β = −0.3, 95% CI −0.5 to −0.2, P < 0.001), but beyond the inflection point, this relationship disappeared (β = 0.0, 95% CI −0.1 to 0.1 P = 0.848). In the group with lower fasting blood glucose (fasting blood glucose <4.6 mmol/L), smoking (interaction P = 0.037) and alcohol consumption (interaction P = 0.001) influenced the relationship between fasting blood glucose and urea.ConclusionsThe results suggest that lower fasting blood glucose was associated with higher urea in non-diabetic individuals with fasting blood glucose <4.6 mmol/L, revealing an L-shaped association between fasting blood glucose and urea.https://www.frontiersin.org/articles/10.3389/fnut.2025.1504855/fullureafasting blood glucosenon-diabetic populationproteinassociation |
| spellingShingle | Chenguang Wu Zhenyan Xu Zhenyan Xu Xin Chen Hualong Liu Yuliang Chen Jiaxing Huang Teng Lu Zixi Huang L-shaped association between fasting blood glucose and urea in a non-diabetic population Frontiers in Nutrition urea fasting blood glucose non-diabetic population protein association |
| title | L-shaped association between fasting blood glucose and urea in a non-diabetic population |
| title_full | L-shaped association between fasting blood glucose and urea in a non-diabetic population |
| title_fullStr | L-shaped association between fasting blood glucose and urea in a non-diabetic population |
| title_full_unstemmed | L-shaped association between fasting blood glucose and urea in a non-diabetic population |
| title_short | L-shaped association between fasting blood glucose and urea in a non-diabetic population |
| title_sort | l shaped association between fasting blood glucose and urea in a non diabetic population |
| topic | urea fasting blood glucose non-diabetic population protein association |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1504855/full |
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