GAS reduced inflammatory responses in activated microglia by regulating the Ccr2/Akt/Gsk-3β pathway

GAS reduced inflammatory responses in activated microglia by regulating the Ccr2/Akt/Gsk-3β pathway

Abstract Hypoxic-ischemic brain damage (HIBD) is a significant cause of neonatal death and neurological dysfunction. Following this injury, activated microglia can lead to a series of inflammatory responses. Gastrodin (GAS), a polyphenol extracted from the Chinese herbal medicine Gastrodia elata Blu...

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Bibliographic Details
Main Authors: Haolong Shi, Jinsha Shi, Zhao Wang, Hanjun Zuo, Tao Guo, Huixin Zheng, Rong Xiao, Xinglin Zhang, Shuhan Yang, Juanjuan Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Brain
Subjects:
GAS
Microglia
Hypoxic-ischemic brain damage
Ccr2/Akt/Gsk-3β
Online Access:https://doi.org/10.1186/s13041-025-01206-w
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