Sophora moocroftiana seeds ethanol extract regulates NLRP3 inflammasome activation and pyroptosis via ROS/TXNIP pathway to amelioration of NAFLD in vitro and in vivo

Sophora moocroftiana seeds ethanol extract regulates NLRP3 inflammasome activation and pyroptosis via ROS/TXNIP pathway to amelioration of NAFLD in vitro and in vivo

BackgroundSophora moorcroftiana (Benth.) Baker is a perennial shrub endemic to the Tibetan Plateau. Its seeds are traditional Tibetan medicine for treating jaundice, hepatitis, purulent tonsillitis, diphtheria, and parasitosis.Aim of the studyThe aim of this research is to explore the possible proce...

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Bibliographic Details
Main Authors: Ruiying Yuan, Mingan Gui, Shan Huang, Yangzhen Ciren, Dongzhi Zhuoma, Guibin Yang, Wendong Zhang, Sicen Wang, Bin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
Sophora moocroftiana seeds
non-alcoholic fatty liver disease
pyroptosis
NLRP3 inflammasome
ROS/TXNIP pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1622178/full
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