Histology of Myopic Dome-Shaped Macula
Introduction: The aim of the study was to examine the histological correlate of a dome-shaped macula in highly myopic human eyes. Case Presentation: We examined histomorphometrically the histological section of an enucleated, axially extremely elongated globe (axial length: 32.0 mm) of a...
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Karger Publishers
2024-11-01
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| Series: | Case Reports in Ophthalmology |
| Online Access: | https://karger.com/article/doi/10.1159/000542070 |
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| author | Songhomitra Panda-Jonas Jost B. Jonas Shefali B. Jonas Rahul A. Jonas |
| author_facet | Songhomitra Panda-Jonas Jost B. Jonas Shefali B. Jonas Rahul A. Jonas |
| author_sort | Songhomitra Panda-Jonas |
| collection | DOAJ |
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Introduction: The aim of the study was to examine the histological correlate of a dome-shaped macula in highly myopic human eyes. Case Presentation: We examined histomorphometrically the histological section of an enucleated, axially extremely elongated globe (axial length: 32.0 mm) of a Caucasian patient aged 56 years. The histological slide exhibited in the foveal region a localized scleral thickening up to 535 µm as compared to a scleral thickness of 298 µm and 310 µm in the parafoveal region. The choroid was thicker in the fovea than parafoveally (21 µm vs. 15 µm). Bruch’s membrane (BM) had a foveal defect (length: 19 µm), at one end of which BM was corrugated. The BM defect was spatially correlated with a subretinal proliferation of retinal pigment epithelium (RPE) cells. Within this subretinal fibrous mass, the RPE cells were connected with a PAS (periodic-acid-Schiff)-positive basal membrane. In the direction of the optic nerve head, BM ended at a distance of 3.8 mm from the optic disc, indicating a large parapapillary gamma zone. The BM end in direction to the optic disc showed a BM corrugation, suggesting a rupture of the lengthened and thinned choroidal peripapillary border tissue. Within parapapillary gamma zone, the peripapillary scleral flange (parapapillary delta zone) was elongated to a length of 0.42 mm and thinned to 94 µm. Conclusions: These histomorphometric findings agree with clinical, optical coherence tomography-based observations of eyes with DSMs, confirm the association of DSMs with macular BM defects, and support the notion of BM playing a role in the biomechanics of the eye. |
| format | Article |
| id | doaj-art-49f521e948d74aaaa40ae601cf7a362d |
| institution | DOAJ |
| issn | 1663-2699 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Karger Publishers |
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| series | Case Reports in Ophthalmology |
| spelling | doaj-art-49f521e948d74aaaa40ae601cf7a362d2025-08-20T03:09:48ZengKarger PublishersCase Reports in Ophthalmology1663-26992024-11-0115178479010.1159/000542070Histology of Myopic Dome-Shaped MaculaSonghomitra Panda-JonasJost B. JonasShefali B. JonasRahul A. Jonas Introduction: The aim of the study was to examine the histological correlate of a dome-shaped macula in highly myopic human eyes. Case Presentation: We examined histomorphometrically the histological section of an enucleated, axially extremely elongated globe (axial length: 32.0 mm) of a Caucasian patient aged 56 years. The histological slide exhibited in the foveal region a localized scleral thickening up to 535 µm as compared to a scleral thickness of 298 µm and 310 µm in the parafoveal region. The choroid was thicker in the fovea than parafoveally (21 µm vs. 15 µm). Bruch’s membrane (BM) had a foveal defect (length: 19 µm), at one end of which BM was corrugated. The BM defect was spatially correlated with a subretinal proliferation of retinal pigment epithelium (RPE) cells. Within this subretinal fibrous mass, the RPE cells were connected with a PAS (periodic-acid-Schiff)-positive basal membrane. In the direction of the optic nerve head, BM ended at a distance of 3.8 mm from the optic disc, indicating a large parapapillary gamma zone. The BM end in direction to the optic disc showed a BM corrugation, suggesting a rupture of the lengthened and thinned choroidal peripapillary border tissue. Within parapapillary gamma zone, the peripapillary scleral flange (parapapillary delta zone) was elongated to a length of 0.42 mm and thinned to 94 µm. Conclusions: These histomorphometric findings agree with clinical, optical coherence tomography-based observations of eyes with DSMs, confirm the association of DSMs with macular BM defects, and support the notion of BM playing a role in the biomechanics of the eye. https://karger.com/article/doi/10.1159/000542070 |
| spellingShingle | Songhomitra Panda-Jonas Jost B. Jonas Shefali B. Jonas Rahul A. Jonas Histology of Myopic Dome-Shaped Macula Case Reports in Ophthalmology |
| title | Histology of Myopic Dome-Shaped Macula |
| title_full | Histology of Myopic Dome-Shaped Macula |
| title_fullStr | Histology of Myopic Dome-Shaped Macula |
| title_full_unstemmed | Histology of Myopic Dome-Shaped Macula |
| title_short | Histology of Myopic Dome-Shaped Macula |
| title_sort | histology of myopic dome shaped macula |
| url | https://karger.com/article/doi/10.1159/000542070 |
| work_keys_str_mv | AT songhomitrapandajonas histologyofmyopicdomeshapedmacula AT jostbjonas histologyofmyopicdomeshapedmacula AT shefalibjonas histologyofmyopicdomeshapedmacula AT rahulajonas histologyofmyopicdomeshapedmacula |