Short-Term Reproducibility of the Inflammatory Phenotype in Different Subgroups of Adult Asthma Cohort
Inflammatory phenotype classification using induced sputum appears attractive as it can be applied to inflammation-based management of the patients with asthma. The aim of the study was to determine the reproducibility of inflammatory phenotype over time in patients with asthma. In 66 adults asthma...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/419039 |
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| author | Sebastian Majewski Maciej Ciebiada Mateusz Domagala Zofia Kurmanowska Pawel Gorski |
| author_facet | Sebastian Majewski Maciej Ciebiada Mateusz Domagala Zofia Kurmanowska Pawel Gorski |
| author_sort | Sebastian Majewski |
| collection | DOAJ |
| description | Inflammatory phenotype classification using induced sputum appears attractive as it can be applied to inflammation-based management of the patients with asthma. The aim of the study was to determine the reproducibility of inflammatory phenotype over time in patients with asthma. In 66 adults asthma was categorized as steroid-naïve (SN, n=17), mild to moderate (MMA, n=33), and refractory treated with oral corticosteroids (RA, n=16). Clinical assessment, skin prick testing, spirometry, and two sputum inductions in 4–6-week interval were done. Inflammatory phenotypes were classified as eosinophilic (EA), consisting of eosinophilic and mixed granulocytic phenotypes, and noneosinophilic (NEA) consisting of paucigranulocytic and neutrophilic phenotypes. During study asthma treatment remained constant. In SN group 25% of patients changed phenotype from EA to NEA and 44% changed phenotype from NEA to EA. In MMA group 26% of patients changed phenotype from EA to NEA and 50% changed phenotype from NEA to EA. In 29% of RA patients inflammatory phenotype changed from EA to NEA and in 22% it changed from NEA to EA. Inflammatory classification, using induced sputum, is not fully reproducible in adults with asthma in short-term evaluation. EA seems to be more stable phenotype across all subgroups whereas NEA remained stable only in RA group. |
| format | Article |
| id | doaj-art-49f4a35a98ae44a5943bc428c2da3d54 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-49f4a35a98ae44a5943bc428c2da3d542025-08-20T03:34:17ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/419039419039Short-Term Reproducibility of the Inflammatory Phenotype in Different Subgroups of Adult Asthma CohortSebastian Majewski0Maciej Ciebiada1Mateusz Domagala2Zofia Kurmanowska3Pawel Gorski4Department of Pneumology and Allergy, Medical University of Lodz, Kopcinskiego Street 22, 90-153 Lodz, PolandDepartment of General and Oncological Pneumology, Medical University of Lodz, Kopcinskiego Street 22, 90-153 Lodz, PolandDepartment of Pneumology and Allergy, Medical University of Lodz, Kopcinskiego Street 22, 90-153 Lodz, PolandDepartment of Pneumology and Allergy, Medical University of Lodz, Kopcinskiego Street 22, 90-153 Lodz, PolandDepartment of Pneumology and Allergy, Medical University of Lodz, Kopcinskiego Street 22, 90-153 Lodz, PolandInflammatory phenotype classification using induced sputum appears attractive as it can be applied to inflammation-based management of the patients with asthma. The aim of the study was to determine the reproducibility of inflammatory phenotype over time in patients with asthma. In 66 adults asthma was categorized as steroid-naïve (SN, n=17), mild to moderate (MMA, n=33), and refractory treated with oral corticosteroids (RA, n=16). Clinical assessment, skin prick testing, spirometry, and two sputum inductions in 4–6-week interval were done. Inflammatory phenotypes were classified as eosinophilic (EA), consisting of eosinophilic and mixed granulocytic phenotypes, and noneosinophilic (NEA) consisting of paucigranulocytic and neutrophilic phenotypes. During study asthma treatment remained constant. In SN group 25% of patients changed phenotype from EA to NEA and 44% changed phenotype from NEA to EA. In MMA group 26% of patients changed phenotype from EA to NEA and 50% changed phenotype from NEA to EA. In 29% of RA patients inflammatory phenotype changed from EA to NEA and in 22% it changed from NEA to EA. Inflammatory classification, using induced sputum, is not fully reproducible in adults with asthma in short-term evaluation. EA seems to be more stable phenotype across all subgroups whereas NEA remained stable only in RA group.http://dx.doi.org/10.1155/2015/419039 |
| spellingShingle | Sebastian Majewski Maciej Ciebiada Mateusz Domagala Zofia Kurmanowska Pawel Gorski Short-Term Reproducibility of the Inflammatory Phenotype in Different Subgroups of Adult Asthma Cohort Mediators of Inflammation |
| title | Short-Term Reproducibility of the Inflammatory Phenotype in Different Subgroups of Adult Asthma Cohort |
| title_full | Short-Term Reproducibility of the Inflammatory Phenotype in Different Subgroups of Adult Asthma Cohort |
| title_fullStr | Short-Term Reproducibility of the Inflammatory Phenotype in Different Subgroups of Adult Asthma Cohort |
| title_full_unstemmed | Short-Term Reproducibility of the Inflammatory Phenotype in Different Subgroups of Adult Asthma Cohort |
| title_short | Short-Term Reproducibility of the Inflammatory Phenotype in Different Subgroups of Adult Asthma Cohort |
| title_sort | short term reproducibility of the inflammatory phenotype in different subgroups of adult asthma cohort |
| url | http://dx.doi.org/10.1155/2015/419039 |
| work_keys_str_mv | AT sebastianmajewski shorttermreproducibilityoftheinflammatoryphenotypeindifferentsubgroupsofadultasthmacohort AT maciejciebiada shorttermreproducibilityoftheinflammatoryphenotypeindifferentsubgroupsofadultasthmacohort AT mateuszdomagala shorttermreproducibilityoftheinflammatoryphenotypeindifferentsubgroupsofadultasthmacohort AT zofiakurmanowska shorttermreproducibilityoftheinflammatoryphenotypeindifferentsubgroupsofadultasthmacohort AT pawelgorski shorttermreproducibilityoftheinflammatoryphenotypeindifferentsubgroupsofadultasthmacohort |