Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients
Purpose: To evaluate the efficacy and safety of 1% pilocarpine to enhance near vision in pseudophakic patients with monofocal intraocular lens (IOL). Methods: This prospective, nonrandomized, open-label, pre–post interventional study was conducted on patients who had a history of phacoemulsificati...
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Knowledge E
2025-05-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | https://knepublishing.com/index.php/JOVR/article/view/15331 |
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| author | Alireza Peyman Maryam Naderi-Lordejani Matin Irajpour Mohammad Javad Ghanbarnia Nima Koosha Mohsen Pourazizi |
| author_facet | Alireza Peyman Maryam Naderi-Lordejani Matin Irajpour Mohammad Javad Ghanbarnia Nima Koosha Mohsen Pourazizi |
| author_sort | Alireza Peyman |
| collection | DOAJ |
| description |
Purpose: To evaluate the efficacy and safety of 1% pilocarpine to enhance near vision in pseudophakic patients with monofocal intraocular lens (IOL).
Methods: This prospective, nonrandomized, open-label, pre–post interventional study was conducted on patients who had a history of phacoemulsification and monofocal IOL implantation without any complications at least six months before the intervention. One drop of 1% pilocarpine solution was instilled in one of the patients’ eyes, and near and distance visual acuity was assessed before and 20 minutes after monocular administration of the drop. Adverse effects were monitored for 8 hours.
Results: We studied 54 pseudophakic eyes of 54 patients with a mean age of 55.02 ±10.10 years, including 36 males (66.7%). Distance-corrected near visual acuity improved significantly after administering 1% pilocarpine (P < 0.001). After treatment, no significant decrease in corrected distance visual acuity (CDVA) was observed (P = 0.60). Overall, 46 patients (85.2%) exhibited an improvement of more than one line in near vision after treatment; however, eight patients (14.8%) did not show any changes in near vision. Only two patients (3.7%) gained three lines in near vision. Headache, irritation, and nausea were observed in three patients, two patients, and one patient, respectively.
Conclusion: The monocular 1% pilocarpine solution significantly improved near visual acuity among patients with pseudophakia and featured an acceptable safety profile. Although this improvement is considerable, it may not be sufficient for complete spectacle independence. Trial registration: ClinicalTrials.gov identifier: NCT05578001
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| format | Article |
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| institution | OA Journals |
| issn | 2008-2010 2008-322X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Knowledge E |
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| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj-art-49f4533a5dd543eea2de3cc43d3b920d2025-08-20T02:34:42ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2025-05-012010.18502/jovr.v20.15331Pilocarpine 1% for Improved Near Vision in Pseudophakic PatientsAlireza Peyman0https://orcid.org/0000-0001-7687-8811Maryam Naderi-Lordejani1https://orcid.org/0000-0001-5242-1534Matin Irajpour2https://orcid.org/0000-0001-8504-9652Mohammad Javad Ghanbarnia3https://orcid.org/0000-0003-1196-5919Nima Koosha4https://orcid.org/0000-0002-1951-0436Mohsen Pourazizi5https://orcid.org/0000-0002-9714-8209Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, IsfahanIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, IsfahanIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, IsfahanDepartment of Ophthalmology, Babol University of Medical Sciences, BabolIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, IsfahanIsfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan Purpose: To evaluate the efficacy and safety of 1% pilocarpine to enhance near vision in pseudophakic patients with monofocal intraocular lens (IOL). Methods: This prospective, nonrandomized, open-label, pre–post interventional study was conducted on patients who had a history of phacoemulsification and monofocal IOL implantation without any complications at least six months before the intervention. One drop of 1% pilocarpine solution was instilled in one of the patients’ eyes, and near and distance visual acuity was assessed before and 20 minutes after monocular administration of the drop. Adverse effects were monitored for 8 hours. Results: We studied 54 pseudophakic eyes of 54 patients with a mean age of 55.02 ±10.10 years, including 36 males (66.7%). Distance-corrected near visual acuity improved significantly after administering 1% pilocarpine (P < 0.001). After treatment, no significant decrease in corrected distance visual acuity (CDVA) was observed (P = 0.60). Overall, 46 patients (85.2%) exhibited an improvement of more than one line in near vision after treatment; however, eight patients (14.8%) did not show any changes in near vision. Only two patients (3.7%) gained three lines in near vision. Headache, irritation, and nausea were observed in three patients, two patients, and one patient, respectively. Conclusion: The monocular 1% pilocarpine solution significantly improved near visual acuity among patients with pseudophakia and featured an acceptable safety profile. Although this improvement is considerable, it may not be sufficient for complete spectacle independence. Trial registration: ClinicalTrials.gov identifier: NCT05578001 https://knepublishing.com/index.php/JOVR/article/view/15331Cataract SurgeryPilocarpinePresbyopiaPseudophakia |
| spellingShingle | Alireza Peyman Maryam Naderi-Lordejani Matin Irajpour Mohammad Javad Ghanbarnia Nima Koosha Mohsen Pourazizi Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients Journal of Ophthalmic & Vision Research Cataract Surgery Pilocarpine Presbyopia Pseudophakia |
| title | Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients |
| title_full | Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients |
| title_fullStr | Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients |
| title_full_unstemmed | Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients |
| title_short | Pilocarpine 1% for Improved Near Vision in Pseudophakic Patients |
| title_sort | pilocarpine 1 for improved near vision in pseudophakic patients |
| topic | Cataract Surgery Pilocarpine Presbyopia Pseudophakia |
| url | https://knepublishing.com/index.php/JOVR/article/view/15331 |
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