Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men
Oral health status is known to be associated with lifestyle-related diseases such as diabetes and chronic kidney disease. In Japan, around 40% of hemodialysis cases are patients with diabetic nephropathy. The aim of this study was to clarify the association between oral health status and diabetic ne...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/4042129 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850104203856314368 |
|---|---|
| author | Masami Yoshioka Yoshifumi Okamoto Masahiro Murata Makoto Fukui Shizuko Yanagisawa Yasuhiko Shirayama Kojiro Nagai Daisuke Hinode |
| author_facet | Masami Yoshioka Yoshifumi Okamoto Masahiro Murata Makoto Fukui Shizuko Yanagisawa Yasuhiko Shirayama Kojiro Nagai Daisuke Hinode |
| author_sort | Masami Yoshioka |
| collection | DOAJ |
| description | Oral health status is known to be associated with lifestyle-related diseases such as diabetes and chronic kidney disease. In Japan, around 40% of hemodialysis cases are patients with diabetic nephropathy. The aim of this study was to clarify the association between oral health status and diabetic nephropathy-related indices in Japanese middle-aged men. Sixty-six men (age range: 55–64 years) with ≥20 remaining teeth and who received public medical checkups and oral examinations were enrolled. We examined correlations of age, body mass index, HbA1c, HDL-C, LDL-C, neutral fat, serum creatinine, and the estimated glomerular filtration rate (eGFR) with the number of remaining teeth or the community periodontal index (CPI) score (periodontal pocket<4 mm: 0, 4–6 mm: 1, ≥6 mm: 2). A positive correlation between the CPI score and serum creatinine and a negative correlation between CPI score and eGFR (Spearman’s rank correlation coefficient, r=0.459, p<0.01, and r=−0.460, p<0.01, respectively) were observed. The mean eGFR in the CPI score 0 group was significantly higher than that in the CPI score 1/2 group (82.6 vs. 70.7, Student’s t-test, p<0.01). Logistic regression analysis using eGFR as a dependent variable and age, CPI score, body mass index, HbA1c, and neutral fat as independent variables suggested that low eGFR (<60) could be attributed to CPI score (OR=3.169, 95% CI: 1.031–9.742, p=0.044). These results suggest a possible association between periodontal status and renal function in Japanese middle-aged men. Periodontal condition is controlled by oral prophylaxis, and periodontal disease and chronic kidney disease have some common risk factors. Thus, periodontal management can contribute to the prevention of severe chronic kidney disease. |
| format | Article |
| id | doaj-art-49f1591ae57a4752bf6df10655ea25ce |
| institution | DOAJ |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-49f1591ae57a4752bf6df10655ea25ce2025-08-20T02:39:22ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/40421294042129Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged MenMasami Yoshioka0Yoshifumi Okamoto1Masahiro Murata2Makoto Fukui3Shizuko Yanagisawa4Yasuhiko Shirayama5Kojiro Nagai6Daisuke Hinode7Department of Oral Health Sciences, Faculty of Health and Welfare, Tokushima Bunri University, 180 Nishihamaboji Yamashirocho Tokushima, 770-8514, JapanTokushima Dental Association, 1-8-65 Kitatamiya, Tokushima 770-0003, JapanTokushima Dental Association, 1-8-65 Kitatamiya, Tokushima 770-0003, JapanTokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramotocho, Tokushima 770-8504, JapanTokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramotocho, Tokushima 770-8504, JapanTokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramotocho, Tokushima 770-8504, JapanTokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramotocho, Tokushima 770-8504, JapanTokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramotocho, Tokushima 770-8504, JapanOral health status is known to be associated with lifestyle-related diseases such as diabetes and chronic kidney disease. In Japan, around 40% of hemodialysis cases are patients with diabetic nephropathy. The aim of this study was to clarify the association between oral health status and diabetic nephropathy-related indices in Japanese middle-aged men. Sixty-six men (age range: 55–64 years) with ≥20 remaining teeth and who received public medical checkups and oral examinations were enrolled. We examined correlations of age, body mass index, HbA1c, HDL-C, LDL-C, neutral fat, serum creatinine, and the estimated glomerular filtration rate (eGFR) with the number of remaining teeth or the community periodontal index (CPI) score (periodontal pocket<4 mm: 0, 4–6 mm: 1, ≥6 mm: 2). A positive correlation between the CPI score and serum creatinine and a negative correlation between CPI score and eGFR (Spearman’s rank correlation coefficient, r=0.459, p<0.01, and r=−0.460, p<0.01, respectively) were observed. The mean eGFR in the CPI score 0 group was significantly higher than that in the CPI score 1/2 group (82.6 vs. 70.7, Student’s t-test, p<0.01). Logistic regression analysis using eGFR as a dependent variable and age, CPI score, body mass index, HbA1c, and neutral fat as independent variables suggested that low eGFR (<60) could be attributed to CPI score (OR=3.169, 95% CI: 1.031–9.742, p=0.044). These results suggest a possible association between periodontal status and renal function in Japanese middle-aged men. Periodontal condition is controlled by oral prophylaxis, and periodontal disease and chronic kidney disease have some common risk factors. Thus, periodontal management can contribute to the prevention of severe chronic kidney disease.http://dx.doi.org/10.1155/2020/4042129 |
| spellingShingle | Masami Yoshioka Yoshifumi Okamoto Masahiro Murata Makoto Fukui Shizuko Yanagisawa Yasuhiko Shirayama Kojiro Nagai Daisuke Hinode Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men Journal of Diabetes Research |
| title | Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men |
| title_full | Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men |
| title_fullStr | Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men |
| title_full_unstemmed | Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men |
| title_short | Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men |
| title_sort | association between oral health status and diabetic nephropathy related indices in japanese middle aged men |
| url | http://dx.doi.org/10.1155/2020/4042129 |
| work_keys_str_mv | AT masamiyoshioka associationbetweenoralhealthstatusanddiabeticnephropathyrelatedindicesinjapanesemiddleagedmen AT yoshifumiokamoto associationbetweenoralhealthstatusanddiabeticnephropathyrelatedindicesinjapanesemiddleagedmen AT masahiromurata associationbetweenoralhealthstatusanddiabeticnephropathyrelatedindicesinjapanesemiddleagedmen AT makotofukui associationbetweenoralhealthstatusanddiabeticnephropathyrelatedindicesinjapanesemiddleagedmen AT shizukoyanagisawa associationbetweenoralhealthstatusanddiabeticnephropathyrelatedindicesinjapanesemiddleagedmen AT yasuhikoshirayama associationbetweenoralhealthstatusanddiabeticnephropathyrelatedindicesinjapanesemiddleagedmen AT kojironagai associationbetweenoralhealthstatusanddiabeticnephropathyrelatedindicesinjapanesemiddleagedmen AT daisukehinode associationbetweenoralhealthstatusanddiabeticnephropathyrelatedindicesinjapanesemiddleagedmen |