Tyrosine phosphatase SHP2 promoted the progression of CRC via modulating the PI3K/BRD4/TFEB signaling induced ferroptosis

Tyrosine phosphatase SHP2 promoted the progression of CRC via modulating the PI3K/BRD4/TFEB signaling induced ferroptosis

Abstract Objective To elucidate the mechanism by which tyrosine phosphatase SHP2 protects CRC through modulation of TFEB-mediated ferritinophagy, thereby suppressing ROS and ferroptosis. Methods SW480 and SW620 cells, in the logarithmic growth phase, were treated with or without the SHP2 inhibitor P...

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Bibliographic Details
Main Authors: Jian Chen, Wei Li, Cheng Zhang, Dihao Wen, Cheng Jiao
Format: Article
Language:English
Published: Springer 2024-12-01
Series:Discover Oncology
Subjects:
CRC
SHP2
TFEB
Ferritinophagy
Ferroptosis
Online Access:https://doi.org/10.1007/s12672-024-01586-w
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