Differential activation of monocytes and PMNs in orofacial granulomatosis patients induced by bacterial and non-bacterial stimuli

Differential activation of monocytes and PMNs in orofacial granulomatosis patients induced by bacterial and non-bacterial stimuli

IntroductionOrofacial Granulomatosis (OFG) is a rare chronic inflammatory disorder characterized by persistent or recurrent swelling of the lips and oral mucosa, often accompanied by granulomatous inflammation in the orofacial region with limited effective treatment options available. Emerging evide...

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Main Authors: Francesco Palestra, Luca Modestino, Annagioia Ventrici, Arianna Monteforte, Gina Memoli, Anne Lise Ferrara, Leonardo Cristinziano, Remo Poto, Francesca Wanda Rossi, Gilda Varricchi, Amato De Paulis, Gianni Marone, Giuseppe Spadaro, Angelica Petraroli, Stefania Loffredo, Maria Rosaria Galdiero
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
cytokines/chemokines
ROS
NETs
bacterial stimuli
inflammation
immunopathogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1522495/full
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