DISTURBANCE OF THE CARDIOMYOCYTE’S MACROMOLECULAR STRUCTURE IN HEART ALLOGRAFTS AS A SIGN OF CHRONIC REJECTION
Chronic rejection, especially cardiac allograft vasculopathy, is a major limiting factor for long-term transplant survival. This process affects not only the blood vessels, but also cardiomyocytes. However, there are extremely few reports on the evaluation of their macromolecular structure state. Th...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2012-12-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/210 |
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| author | A. G. Kupriyanova L. V. Beletskaya I. M. Ilyinsky V. A. Zaidenov N. P. Mozeiko R. S. Saitgareev A. Y. Kormer A. M. Golts V. M. Zakharevich S. V. Gautier |
| author_facet | A. G. Kupriyanova L. V. Beletskaya I. M. Ilyinsky V. A. Zaidenov N. P. Mozeiko R. S. Saitgareev A. Y. Kormer A. M. Golts V. M. Zakharevich S. V. Gautier |
| author_sort | A. G. Kupriyanova |
| collection | DOAJ |
| description | Chronic rejection, especially cardiac allograft vasculopathy, is a major limiting factor for long-term transplant survival. This process affects not only the blood vessels, but also cardiomyocytes. However, there are extremely few reports on the evaluation of their macromolecular structure state. The aim of the study was to evaluate the structural proteins of cardiomyocytes (actin, myosin, troponin I, titin, desmin, vinculin) of heart allografts in different periods after the operation (from 6 days to 15 years). Major changes of macromolecular structure were revealed in late period after transplantation (6 months – 15 years). The contribution of humoral immune response in the process of chronic cardiac allograft rejection was observed: in eight of twelve recipients episodes of acute humoral rejection had been repeatedly registered; disorders of the expression of 5 proteins out of 6 characterized were found in recipients with recurrent and persistent antibody-mediated rejection. |
| format | Article |
| id | doaj-art-49e329366d73426caabc55248a596a62 |
| institution | Kabale University |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2012-12-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-49e329366d73426caabc55248a596a622025-08-20T03:59:56ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912012-12-01144172610.15825/1995-1191-2012-4-17-26153DISTURBANCE OF THE CARDIOMYOCYTE’S MACROMOLECULAR STRUCTURE IN HEART ALLOGRAFTS AS A SIGN OF CHRONIC REJECTIONA. G. Kupriyanova0L. V. Beletskaya1I. M. Ilyinsky2V. A. Zaidenov3N. P. Mozeiko4R. S. Saitgareev5A. Y. Kormer6A. M. Golts7V. M. Zakharevich8S. V. Gautier9Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, I.M. Sechenov First Moscow State Medical University, Department of transplantology and artificial organsChronic rejection, especially cardiac allograft vasculopathy, is a major limiting factor for long-term transplant survival. This process affects not only the blood vessels, but also cardiomyocytes. However, there are extremely few reports on the evaluation of their macromolecular structure state. The aim of the study was to evaluate the structural proteins of cardiomyocytes (actin, myosin, troponin I, titin, desmin, vinculin) of heart allografts in different periods after the operation (from 6 days to 15 years). Major changes of macromolecular structure were revealed in late period after transplantation (6 months – 15 years). The contribution of humoral immune response in the process of chronic cardiac allograft rejection was observed: in eight of twelve recipients episodes of acute humoral rejection had been repeatedly registered; disorders of the expression of 5 proteins out of 6 characterized were found in recipients with recurrent and persistent antibody-mediated rejection.https://journal.transpl.ru/vtio/article/view/210structural proteinscardiomyocyteshumoral (antibody-mediated) rejectionchronic rejection |
| spellingShingle | A. G. Kupriyanova L. V. Beletskaya I. M. Ilyinsky V. A. Zaidenov N. P. Mozeiko R. S. Saitgareev A. Y. Kormer A. M. Golts V. M. Zakharevich S. V. Gautier DISTURBANCE OF THE CARDIOMYOCYTE’S MACROMOLECULAR STRUCTURE IN HEART ALLOGRAFTS AS A SIGN OF CHRONIC REJECTION Вестник трансплантологии и искусственных органов structural proteins cardiomyocytes humoral (antibody-mediated) rejection chronic rejection |
| title | DISTURBANCE OF THE CARDIOMYOCYTE’S MACROMOLECULAR STRUCTURE IN HEART ALLOGRAFTS AS A SIGN OF CHRONIC REJECTION |
| title_full | DISTURBANCE OF THE CARDIOMYOCYTE’S MACROMOLECULAR STRUCTURE IN HEART ALLOGRAFTS AS A SIGN OF CHRONIC REJECTION |
| title_fullStr | DISTURBANCE OF THE CARDIOMYOCYTE’S MACROMOLECULAR STRUCTURE IN HEART ALLOGRAFTS AS A SIGN OF CHRONIC REJECTION |
| title_full_unstemmed | DISTURBANCE OF THE CARDIOMYOCYTE’S MACROMOLECULAR STRUCTURE IN HEART ALLOGRAFTS AS A SIGN OF CHRONIC REJECTION |
| title_short | DISTURBANCE OF THE CARDIOMYOCYTE’S MACROMOLECULAR STRUCTURE IN HEART ALLOGRAFTS AS A SIGN OF CHRONIC REJECTION |
| title_sort | disturbance of the cardiomyocyte s macromolecular structure in heart allografts as a sign of chronic rejection |
| topic | structural proteins cardiomyocytes humoral (antibody-mediated) rejection chronic rejection |
| url | https://journal.transpl.ru/vtio/article/view/210 |
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