Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review
BackgroundEvidence suggests that luteolin (LUT) may offer therapeutic potential in treating ulcerative colitis (UC), though its specific pharmacological mechanisms remain incompletely understood. This meta-analysis aims to assess the pharmacological effects of LUT in UC animal models and investigate...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1639644/full |
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| author | Yiyi Feng Xingyao Lu Xingyao Lu Enjia Guo Jianling Mo Yichuan Xv |
| author_facet | Yiyi Feng Xingyao Lu Xingyao Lu Enjia Guo Jianling Mo Yichuan Xv |
| author_sort | Yiyi Feng |
| collection | DOAJ |
| description | BackgroundEvidence suggests that luteolin (LUT) may offer therapeutic potential in treating ulcerative colitis (UC), though its specific pharmacological mechanisms remain incompletely understood. This meta-analysis aims to assess the pharmacological effects of LUT in UC animal models and investigate its potential mechanisms of action.MethodsA comprehensive search of five databases, namely, PubMed, Web of Science, Embase, EBSCO, and ScienceDirect, was conducted to identify studies investigating the effects of LUT on UC. The search, covering data up to March 2025, yielded 19 eligible studies involving a total of 327 animal subjects. The outcomes were analyzed using the standard mean difference with a 95% confidence interval in R (4.3.3) software.ResultsThe meta-analysis revealed that LUT significantly ameliorated colon length, reduced the disease activity index, alleviated body weight loss, and decreased histological scores. Further mechanistic analysis indicated that LUT exerts its effects through multiple mechanisms, including the reduction of pro-inflammatory cytokines, elevation of anti-inflammatory cytokines, promotion of tight junction protein expression, and improvement of oxidative stress-related indices. However, LUT appears to have no significant impact on the α-diversity of the intestinal microbiota.ConclusionThis study suggests that LUT may exert significant therapeutic effects in UC animal models through antioxidant, anti-inflammatory, immunomodulatory, and barrier-protective mechanisms. Further clinical studies and translational research are essential to bridge the gap between animal models and human applications.Systematic Review Registrationhttps://inplasy.com/inplasy-2025-5-0055/, identifier INPLASY202550055. |
| format | Article |
| id | doaj-art-49e3239a89bc4dc590b9def28aaacde8 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-49e3239a89bc4dc590b9def28aaacde82025-08-20T02:46:19ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.16396441639644Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic reviewYiyi Feng0Xingyao Lu1Xingyao Lu2Enjia Guo3Jianling Mo4Yichuan Xv5Department of Traditional Chinese Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, Hangzhou, ChinaDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Traditional Chinese Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaBackgroundEvidence suggests that luteolin (LUT) may offer therapeutic potential in treating ulcerative colitis (UC), though its specific pharmacological mechanisms remain incompletely understood. This meta-analysis aims to assess the pharmacological effects of LUT in UC animal models and investigate its potential mechanisms of action.MethodsA comprehensive search of five databases, namely, PubMed, Web of Science, Embase, EBSCO, and ScienceDirect, was conducted to identify studies investigating the effects of LUT on UC. The search, covering data up to March 2025, yielded 19 eligible studies involving a total of 327 animal subjects. The outcomes were analyzed using the standard mean difference with a 95% confidence interval in R (4.3.3) software.ResultsThe meta-analysis revealed that LUT significantly ameliorated colon length, reduced the disease activity index, alleviated body weight loss, and decreased histological scores. Further mechanistic analysis indicated that LUT exerts its effects through multiple mechanisms, including the reduction of pro-inflammatory cytokines, elevation of anti-inflammatory cytokines, promotion of tight junction protein expression, and improvement of oxidative stress-related indices. However, LUT appears to have no significant impact on the α-diversity of the intestinal microbiota.ConclusionThis study suggests that LUT may exert significant therapeutic effects in UC animal models through antioxidant, anti-inflammatory, immunomodulatory, and barrier-protective mechanisms. Further clinical studies and translational research are essential to bridge the gap between animal models and human applications.Systematic Review Registrationhttps://inplasy.com/inplasy-2025-5-0055/, identifier INPLASY202550055.https://www.frontiersin.org/articles/10.3389/fphar.2025.1639644/fullluteolinulcerative colitissystematic reviewmeta analysisanimal model |
| spellingShingle | Yiyi Feng Xingyao Lu Xingyao Lu Enjia Guo Jianling Mo Yichuan Xv Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review Frontiers in Pharmacology luteolin ulcerative colitis systematic review meta analysis animal model |
| title | Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review |
| title_full | Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review |
| title_fullStr | Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review |
| title_full_unstemmed | Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review |
| title_short | Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review |
| title_sort | preclinical evidence for luteolin in ulcerative colitis a meta analysis and systematic review |
| topic | luteolin ulcerative colitis systematic review meta analysis animal model |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1639644/full |
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