Single cell RNA sequencing after moderate traumatic brain injury: effects of therapeutic hypothermia

Single cell RNA sequencing after moderate traumatic brain injury: effects of therapeutic hypothermia

Abstract Traumatic brain injury (TBI) initiates a cascade of cellular and molecular events that promote acute and long-term patterns of neuronal, glial, vascular, and synaptic vulnerability leading to lasting neurological deficits. These complex responses lead to patterns of programmed cell death, d...

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Bibliographic Details
Main Authors: Nadine A. Kerr, James Choi, Simone Y. Mohite, Praveen Kumar Singh, Helen M. Bramlett, Jae K. Lee, W. Dalton Dietrich
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neuroinflammation
Subjects:
Traumatic brain injury
Hypothermia
Single-cell RNA sequencing
Astrocytes
Online Access:https://doi.org/10.1186/s12974-025-03430-6
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