Concomitant Exogenous Cushing Syndrome and Adrenal Insufficiency From Use and Withdrawal of the Supplement Ardosons
Unregulated supplements containing undisclosed glucocorticoids can cause exogenous Cushing syndrome and adrenal suppression on abrupt withdrawal. To our knowledge, we present the first known case of a patient using Ardosons for a decade, an over-the-counter arthritis supplement containing betamethas...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2025-05-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1123 |
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| author | Faidat Adeola Ishola Angela Rao Dimpi Desai Deborah E. Sellmeyer |
| author_facet | Faidat Adeola Ishola Angela Rao Dimpi Desai Deborah E. Sellmeyer |
| author_sort | Faidat Adeola Ishola |
| collection | DOAJ |
| description | Unregulated supplements containing undisclosed glucocorticoids can cause exogenous Cushing syndrome and adrenal suppression on abrupt withdrawal. To our knowledge, we present the first known case of a patient using Ardosons for a decade, an over-the-counter arthritis supplement containing betamethasone leading to hypercortisolism. A 47-year-old man with ankylosing spondylitis developed Cushingoid features with subsequent adrenal insufficiency after abruptly stopping Ardosons. He was treated with hydrocortisone, leading to symptomatic improvement. Five weeks later, he had lost 7.3 kg, with reduced striae. Adrenal function remained suppressed 9 months after presentation. A thorough medication reconciliation is essential to identify hidden corticosteroids in patients with mixed Cushingoid and adrenal insufficiency symptoms. |
| format | Article |
| id | doaj-art-49df5ac2400442ac971c266c097ddbf2 |
| institution | Kabale University |
| issn | 2767-7664 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-49df5ac2400442ac971c266c097ddbf22025-08-20T03:47:41ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-05-014510.7326/aimcc.2024.1123Concomitant Exogenous Cushing Syndrome and Adrenal Insufficiency From Use and Withdrawal of the Supplement ArdosonsFaidat Adeola Ishola0Angela Rao1Dimpi Desai2Deborah E. Sellmeyer31Division of Endocrinology, Gerontology, and Metabolism, Department of Internal Medicine, Stanford Health Care, Palo Alto, California1Division of Endocrinology, Gerontology, and Metabolism, Department of Internal Medicine, Stanford Health Care, Palo Alto, California1Division of Endocrinology, Gerontology, and Metabolism, Department of Internal Medicine, Stanford Health Care, Palo Alto, California1Division of Endocrinology, Gerontology, and Metabolism, Department of Internal Medicine, Stanford Health Care, Palo Alto, CaliforniaUnregulated supplements containing undisclosed glucocorticoids can cause exogenous Cushing syndrome and adrenal suppression on abrupt withdrawal. To our knowledge, we present the first known case of a patient using Ardosons for a decade, an over-the-counter arthritis supplement containing betamethasone leading to hypercortisolism. A 47-year-old man with ankylosing spondylitis developed Cushingoid features with subsequent adrenal insufficiency after abruptly stopping Ardosons. He was treated with hydrocortisone, leading to symptomatic improvement. Five weeks later, he had lost 7.3 kg, with reduced striae. Adrenal function remained suppressed 9 months after presentation. A thorough medication reconciliation is essential to identify hidden corticosteroids in patients with mixed Cushingoid and adrenal insufficiency symptoms.https://www.acpjournals.org/doi/10.7326/aimcc.2024.1123 |
| spellingShingle | Faidat Adeola Ishola Angela Rao Dimpi Desai Deborah E. Sellmeyer Concomitant Exogenous Cushing Syndrome and Adrenal Insufficiency From Use and Withdrawal of the Supplement Ardosons Annals of Internal Medicine: Clinical Cases |
| title | Concomitant Exogenous Cushing Syndrome and Adrenal Insufficiency From Use and Withdrawal of the Supplement Ardosons |
| title_full | Concomitant Exogenous Cushing Syndrome and Adrenal Insufficiency From Use and Withdrawal of the Supplement Ardosons |
| title_fullStr | Concomitant Exogenous Cushing Syndrome and Adrenal Insufficiency From Use and Withdrawal of the Supplement Ardosons |
| title_full_unstemmed | Concomitant Exogenous Cushing Syndrome and Adrenal Insufficiency From Use and Withdrawal of the Supplement Ardosons |
| title_short | Concomitant Exogenous Cushing Syndrome and Adrenal Insufficiency From Use and Withdrawal of the Supplement Ardosons |
| title_sort | concomitant exogenous cushing syndrome and adrenal insufficiency from use and withdrawal of the supplement ardosons |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1123 |
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