Age-Dependent Loss of Sirtuin1 (Sirt1) Correlates with Reduced Autophagy in Type 2 Diabetic Patients (T2DM)

Age-Dependent Loss of Sirtuin1 (Sirt1) Correlates with Reduced Autophagy in Type 2 Diabetic Patients (T2DM)

<b>Aims and Background:</b> Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder frequently associated with increased inflammation and dysregulated innate immune responses. Thus, patients with T2DM are predisposed to bacterial infections. However, the underlying mechanism is p...

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Main Authors: Julia Fischer, Nina Judith Hos, Sophie Tritschler, Joel Schmitz-Peters, Raja Ganesan, Chiara Calabrese, Petra Schiller, Hannah Brunnert, Angela Nowag, Sandra Winter, Ruth Hanßen, Katja Römer, Nazifa Qurishi, Isabelle Suarèz, Norma Jung, Clara Lehmann, Georg Plum, Michael Faust, Pia Hartmann, Nirmal Robinson
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Diabetology
Subjects:
type 2 diabetes mellitus
PBMC
Sirtuin1
autophagy
Online Access:https://www.mdpi.com/2673-4540/6/6/45
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