IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema

IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema

Mesenchymal stem cells (MSCs) can participate in lymphangiogenesis through paracrine effects, while lymphatic endothelial progenitor cells (LEPCs), a subpopulation of endothelial progenitor cells (EPCs), can differentiate into mature lymphatic endothelial cells, thereby influencing lymphatic functio...

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Bibliographic Details
Main Authors: Zekuan Xue, Dongdong Yang, Zhiwei Jin, Yijie Li, Yunfei Yu, Xinchun Zhao, Yongzhou Huang, Shengqiu Jia, Tong Zhang, Guilin Huang, Jixue Hou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Genetics
Subjects:
mesenchymal stem cells
endothelial progenitor cells
proliferation
insulin-like growth factor 1
lymphedema
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1584095/full
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