Intraoperative vasopressor use during emergency surgery on injured meth users
Background Methamphetamine is a growing drug of abuse in America. Patients with recent methamphetamine use pose potential complications to general anesthesia due to changes in hemodynamics and arrhythmias. Limited data exists on the incidence of intraoperative complications on methamphetamine-intoxi...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-12-01
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| Series: | Trauma Surgery & Acute Care Open |
| Online Access: | https://tsaco.bmj.com/content/5/1/e000553.full |
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| _version_ | 1850063010936127488 |
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| author | Alexandra Marie Edwards Eric Gregory Johnson Andrew C. Bernard |
| author_facet | Alexandra Marie Edwards Eric Gregory Johnson Andrew C. Bernard |
| author_sort | Alexandra Marie Edwards |
| collection | DOAJ |
| description | Background Methamphetamine is a growing drug of abuse in America. Patients with recent methamphetamine use pose potential complications to general anesthesia due to changes in hemodynamics and arrhythmias. Limited data exists on the incidence of intraoperative complications on methamphetamine-intoxicated patients requiring urgent or emergent trauma surgery. This study aims to describe intraoperative complications observed in methamphetamine and amphetamine-intoxicated patients requiring emergent surgery.Methods Using the Trauma Registry at our ACS-verified level I trauma center, we completed a single-center, descriptive, retrospective cohort review between July 1, 2012 and June 30, 2016, of adult patients requiring emergent surgery with a positive urine-drug screen for methamphetamines or amphetamines. The objective was to evaluate vasopressor utilization during surgical operation.Results A total of 92 patients were identified with a positive UDS for amphetamine and/or methamphetamine who went to the operating room within 24 hours of admission. Thirty-two (34%) patients received one or more (≥1) doses of vasopressor, while 60 patients (66%) received no vasopressor. Changes in mean arterial pressure (MAP) were noted in 64%, while only 3% experienced an EKG change. A binomial logistic regression showed age, base deficit and change in MAP to be predictive of vasopressor use (p<0.002). No intraoperative cardiac events or anesthetic complications were seen.Discussion Hemodynamic instability in the amphetamine and methamphetamine-intoxicated population may be more directly related to degree of resuscitation required, than the presence of a positive UDS.Level of evidence IV |
| format | Article |
| id | doaj-art-49dce4edeb024ac59b8b63d1dc267f2a |
| institution | DOAJ |
| issn | 2397-5776 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Trauma Surgery & Acute Care Open |
| spelling | doaj-art-49dce4edeb024ac59b8b63d1dc267f2a2025-08-20T02:49:47ZengBMJ Publishing GroupTrauma Surgery & Acute Care Open2397-57762020-12-015110.1136/tsaco-2020-000553Intraoperative vasopressor use during emergency surgery on injured meth usersAlexandra Marie Edwards0Eric Gregory Johnson1Andrew C. Bernard2Department of Obstetrics, Gynecology and Womens’s Health, St. Louis University, St. Louis, Missouri, USADepartment of Pharmacy, University of Kentucky, Lexington, Kentucky, USADepartment of Surgery, University of Kentucky Medical Center, Lexington, Kentucky, USABackground Methamphetamine is a growing drug of abuse in America. Patients with recent methamphetamine use pose potential complications to general anesthesia due to changes in hemodynamics and arrhythmias. Limited data exists on the incidence of intraoperative complications on methamphetamine-intoxicated patients requiring urgent or emergent trauma surgery. This study aims to describe intraoperative complications observed in methamphetamine and amphetamine-intoxicated patients requiring emergent surgery.Methods Using the Trauma Registry at our ACS-verified level I trauma center, we completed a single-center, descriptive, retrospective cohort review between July 1, 2012 and June 30, 2016, of adult patients requiring emergent surgery with a positive urine-drug screen for methamphetamines or amphetamines. The objective was to evaluate vasopressor utilization during surgical operation.Results A total of 92 patients were identified with a positive UDS for amphetamine and/or methamphetamine who went to the operating room within 24 hours of admission. Thirty-two (34%) patients received one or more (≥1) doses of vasopressor, while 60 patients (66%) received no vasopressor. Changes in mean arterial pressure (MAP) were noted in 64%, while only 3% experienced an EKG change. A binomial logistic regression showed age, base deficit and change in MAP to be predictive of vasopressor use (p<0.002). No intraoperative cardiac events or anesthetic complications were seen.Discussion Hemodynamic instability in the amphetamine and methamphetamine-intoxicated population may be more directly related to degree of resuscitation required, than the presence of a positive UDS.Level of evidence IVhttps://tsaco.bmj.com/content/5/1/e000553.full |
| spellingShingle | Alexandra Marie Edwards Eric Gregory Johnson Andrew C. Bernard Intraoperative vasopressor use during emergency surgery on injured meth users Trauma Surgery & Acute Care Open |
| title | Intraoperative vasopressor use during emergency surgery on injured meth users |
| title_full | Intraoperative vasopressor use during emergency surgery on injured meth users |
| title_fullStr | Intraoperative vasopressor use during emergency surgery on injured meth users |
| title_full_unstemmed | Intraoperative vasopressor use during emergency surgery on injured meth users |
| title_short | Intraoperative vasopressor use during emergency surgery on injured meth users |
| title_sort | intraoperative vasopressor use during emergency surgery on injured meth users |
| url | https://tsaco.bmj.com/content/5/1/e000553.full |
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