Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency

Transcranial alternating current stimulation (tACS) can modulate endogenous brain oscillations in a frequency-specific manner. Previous studies have reported that beta tACS modulates the excitability of primary motor cortex and improves task performance. Tactile and proprioceptive stimuli also elici...

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Main Authors: Mayu Akaiwa, Ryo Kurokawa, Yuya Matsuda, Yasushi Sugawara, Rin Kosuge, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Neuroscience Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S0168010225000677
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author Mayu Akaiwa
Ryo Kurokawa
Yuya Matsuda
Yasushi Sugawara
Rin Kosuge
Hidekazu Saito
Eriko Shibata
Takeshi Sasaki
Kazuhiro Sugawara
author_facet Mayu Akaiwa
Ryo Kurokawa
Yuya Matsuda
Yasushi Sugawara
Rin Kosuge
Hidekazu Saito
Eriko Shibata
Takeshi Sasaki
Kazuhiro Sugawara
author_sort Mayu Akaiwa
collection DOAJ
description Transcranial alternating current stimulation (tACS) can modulate endogenous brain oscillations in a frequency-specific manner. Previous studies have reported that beta tACS modulates the excitability of primary motor cortex and improves task performance. Tactile and proprioceptive stimuli also elicit event-related synchronization of the beta rhythm in contralateral sensorimotor cortex, termed beta rebound, and a strong correlation was reported between proprioception-induced rebound strength and clinical recovery in stroke patients. We investigated the effects of tACS matched to the dominant beta frequency on the strength of proprioception-induced beta rebound.We recorded the beta rebound from 14 healthy young adults in response to passive index finger movement by electroencephalography to determine individual peak beta frequency. Electroencephalograms (EEG) were recorded during passive movements before and after active or sham tACS. We recorded beta rebound of all participants to determine their individual peak frequency of beta rebound prior to this experiment. Active tACS at individually matched frequencies increased beta rebound strength during subsequent passive movement compared to sham tACS in the majority of participants, while the remaining participants demonstrated no significant change or a decrease. These findings on healthy participants provide an essential foundation for further studies on the effects of beta frequency-matched tACS for stroke patient rehabilitation.
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spelling doaj-art-49da102dfbc644db80da8e2f083293a42025-08-20T03:44:55ZengElsevierNeuroscience Research0168-01022025-07-0121610489610.1016/j.neures.2025.03.008Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequencyMayu Akaiwa0Ryo Kurokawa1Yuya Matsuda2Yasushi Sugawara3Rin Kosuge4Hidekazu Saito5Eriko Shibata6Takeshi Sasaki7Kazuhiro Sugawara8Department of Physical Therapy, School of Health Sciences, Sapporo Medical University, Sapporo, Hokkaido, Japan; Department of Rehabilitation, Sapporo Hakuyokai Hospital, Sapporo, Hokkaido, Japan; Correspondence to: Sapporo Medical University, South 1 West 17, Chuo-ku, Sapporo 060-8556, Japan.Department of Rehabilitation, Sapporo Hakuyokai Hospital, Sapporo, Hokkaido, JapanGraduate School of Health Sciences, Sapporo Medical University, Sapporo, Hokkaido, JapanDepartment of Rehabilitation, Sapporo Hakuyokai Hospital, Sapporo, Hokkaido, JapanGraduate School of Health Sciences, Sapporo Medical University, Sapporo, Hokkaido, JapanDepartment of Occupational Therapy, School of Health Sciences, Sapporo Medical University, Sapporo, Hokkaido, JapanMajor of Physical Therapy, Department of Rehabilitation, Faculty of Healthcare and Science, Hokkaido Bunkyo University, Eniwa, Hokkaido, JapanDepartment of Physical Therapy, School of Health Sciences, Sapporo Medical University, Sapporo, Hokkaido, JapanDepartment of Physical Therapy, School of Health Sciences, Sapporo Medical University, Sapporo, Hokkaido, JapanTranscranial alternating current stimulation (tACS) can modulate endogenous brain oscillations in a frequency-specific manner. Previous studies have reported that beta tACS modulates the excitability of primary motor cortex and improves task performance. Tactile and proprioceptive stimuli also elicit event-related synchronization of the beta rhythm in contralateral sensorimotor cortex, termed beta rebound, and a strong correlation was reported between proprioception-induced rebound strength and clinical recovery in stroke patients. We investigated the effects of tACS matched to the dominant beta frequency on the strength of proprioception-induced beta rebound.We recorded the beta rebound from 14 healthy young adults in response to passive index finger movement by electroencephalography to determine individual peak beta frequency. Electroencephalograms (EEG) were recorded during passive movements before and after active or sham tACS. We recorded beta rebound of all participants to determine their individual peak frequency of beta rebound prior to this experiment. Active tACS at individually matched frequencies increased beta rebound strength during subsequent passive movement compared to sham tACS in the majority of participants, while the remaining participants demonstrated no significant change or a decrease. These findings on healthy participants provide an essential foundation for further studies on the effects of beta frequency-matched tACS for stroke patient rehabilitation.http://www.sciencedirect.com/science/article/pii/S0168010225000677Transcranial alternating current stimulationEvent-related synchronizationProprioception
spellingShingle Mayu Akaiwa
Ryo Kurokawa
Yuya Matsuda
Yasushi Sugawara
Rin Kosuge
Hidekazu Saito
Eriko Shibata
Takeshi Sasaki
Kazuhiro Sugawara
Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency
Neuroscience Research
Transcranial alternating current stimulation
Event-related synchronization
Proprioception
title Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency
title_full Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency
title_fullStr Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency
title_full_unstemmed Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency
title_short Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency
title_sort enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency
topic Transcranial alternating current stimulation
Event-related synchronization
Proprioception
url http://www.sciencedirect.com/science/article/pii/S0168010225000677
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