Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy
Purpose: To explore the role of thyroid hormone’ receptors in the development of the autoimmune process in orbita.Methods: The intraoperative biopsy material of the lacrimal gland obtained from orbital decompression in patients with autoimmune orbitopathy (AOP) was studied and compared with biopsy m...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2014-07-01
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| Series: | Oftalʹmologiâ |
| Subjects: | |
| Online Access: | https://www.ophthalmojournal.com/opht/article/view/101 |
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| author | V. G. Likhvantseva O. A. Gontyurova E. A. Rudenko T. N. Saphonova K. A. Kuzmin N. Y. Sviridenko |
| author_facet | V. G. Likhvantseva O. A. Gontyurova E. A. Rudenko T. N. Saphonova K. A. Kuzmin N. Y. Sviridenko |
| author_sort | V. G. Likhvantseva |
| collection | DOAJ |
| description | Purpose: To explore the role of thyroid hormone’ receptors in the development of the autoimmune process in orbita.Methods: The intraoperative biopsy material of the lacrimal gland obtained from orbital decompression in patients with autoimmune orbitopathy (AOP) was studied and compared with biopsy material of normal lacrimal gland.Results: The expression of isoforms of thyroid hormone’ receptors in various cellular elements of the lacrimal gland is improved in normal, as well as change their expression when the AOP. This process is associated with change of structure of the lacrimal gland and organ infiltration cells.Conclusion: The findings support the assumption that the lacrimal gland is the target organ, along with orbital and muscles for autoimmune aggression in the AOP. |
| format | Article |
| id | doaj-art-49d77048a4b143f18b477d5cea061e0e |
| institution | Kabale University |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-49d77048a4b143f18b477d5cea061e0e2025-08-20T04:00:25ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452014-07-01103212510.18008/1816-5095-2013-3-21-25101Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathyV. G. Likhvantseva0O. A. Gontyurova1E. A. Rudenko2T. N. Saphonova3K. A. Kuzmin4N. Y. Sviridenko5ФФМ МГУ имени М. В. ЛомоносоваФГБУ Институт глазных болезней РАМНФФМ МГУ имени М. В. ЛомоносоваФГУ Эндокринологический научный центр РосмедтехнологийФФМ МГУ имени М. В. ЛомоносоваФФМ МГУ имени М. В. ЛомоносоваPurpose: To explore the role of thyroid hormone’ receptors in the development of the autoimmune process in orbita.Methods: The intraoperative biopsy material of the lacrimal gland obtained from orbital decompression in patients with autoimmune orbitopathy (AOP) was studied and compared with biopsy material of normal lacrimal gland.Results: The expression of isoforms of thyroid hormone’ receptors in various cellular elements of the lacrimal gland is improved in normal, as well as change their expression when the AOP. This process is associated with change of structure of the lacrimal gland and organ infiltration cells.Conclusion: The findings support the assumption that the lacrimal gland is the target organ, along with orbital and muscles for autoimmune aggression in the AOP.https://www.ophthalmojournal.com/opht/article/view/101autoimmune oritopathylacrimal glandthyroid hormones |
| spellingShingle | V. G. Likhvantseva O. A. Gontyurova E. A. Rudenko T. N. Saphonova K. A. Kuzmin N. Y. Sviridenko Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy Oftalʹmologiâ autoimmune oritopathy lacrimal gland thyroid hormones |
| title | Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy |
| title_full | Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy |
| title_fullStr | Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy |
| title_full_unstemmed | Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy |
| title_short | Studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy |
| title_sort | studying the role of thyroid hormone receptor expression in the lacrimal gland in the autoimmune orbitopathy |
| topic | autoimmune oritopathy lacrimal gland thyroid hormones |
| url | https://www.ophthalmojournal.com/opht/article/view/101 |
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