INFUSION FROM C. COGGYGRIA SCOP. LEAVES ON THE HEPATIC OXIDATIVE STRESS IN MICE WITH DEXTRAN SODIUM SULPHATE (DSS)-INDUCED ULCERATIVE COLITIS
Objective: Since free radicals play a crucial role in ulcerative colitis (UC)- assotiated liver manifestations, antioxidants of plant origin have been proposed as potential therapeutic agents to counteract liver damage. This study aimed to elucidate the ameliorative effect of the aqueous infusion of...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Istanbul University Press
2025-03-01
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| Series: | Sabiad |
| Subjects: | |
| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/5DA1FB032C35440CB7AF2A20B5612091 |
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| Summary: | Objective: Since free radicals play a crucial role in ulcerative colitis (UC)- assotiated liver manifestations, antioxidants of plant origin have been proposed as potential therapeutic agents to counteract liver damage. This study aimed to elucidate the ameliorative effect of the aqueous infusion of the C. coggygria leaves (CCLAI) in comparison with a mesalamine in alleviating the oxidative stress in the liver of mice with DSS-induced UC. Material and Methods: Two different doses of CCLAI (4% and 6%) or mesalamine (250 mg/kg body weight) were administered by oral gavage to C57BL/6 male mice once a day for 7 consecutive days. UC was induced with 3% DSS in drinking water for 5 days, except the normal and plant control groups that had access to water only. Results: No statistical difference between all the groups was observed in the activities of AST and ALT, hepatic damage markers, suggesting that the oxidative alterations were not sufficient to cause liver damage, although oxidative stress occurred. The elevated activities of antioxidant markers (SOD, CAT, GR, GPx, GST) and increased GSH and NO levels in the colitis groups compared with the normal group may represent an initial defence mechanism against oxidative stress. These results indicate that CCLAI may attenuate oxidative stress, as demonstrated by decreased MDA levels and MPO activity and reversed levels of oxidative stress parameters towards the value of normal controls.Conclusion: Our study provided evidence that CCLAI can reduce oxidative stress probably by scavenging ROS and modulating the oxidant/antioxidant balance in hepatic tissues. |
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| ISSN: | 2651-4060 |