Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City
Objective The COVID-19 pandemic is a global public health crisis, with over 33 million cases and 999 000 deaths worldwide. Data are needed regarding the clinical course of hospitalised patients, particularly in the USA. We aimed to compare clinical characteristic of patients with COVID-19 who had in...
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BMJ Publishing Group
2020-11-01
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| Series: | BMJ Open |
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| author | Girish N Nadkarni Zahi A Fayad Benjamin S Glicksberg David L Reich Prem Timsina Arash Kia Patricia Kovatch Jessica K De Freitas Paul O’Reilly Allan Just Dennis Charney Ishan Paranjpe Ross O'Hagan Adam J Russak Anuradha Lala Riccardo Miotto Akhil Vaid Kipp W Johnson Matteo Danieletto Eddye Golden Dara Meyer Manbir Singh Sulaiman Somani Arjun Kapoor Sayan Manna Udit Nangia Suraj K Jaladanki Laura M Huckins Patricia Glowe Robert M Freeman Matthew A Levin Jeffrey Jhang Adolfo Firpo Joseph Finkelstein Judith A Aberg Emilia Bagiella Carol R Horowitz Barbara Murphy Jagat Narula Eric J Nestler V Fuster Carlos Cordon-Cardo Erwin P Bottinger Alexander W Charney |
| author_facet | Girish N Nadkarni Zahi A Fayad Benjamin S Glicksberg David L Reich Prem Timsina Arash Kia Patricia Kovatch Jessica K De Freitas Paul O’Reilly Allan Just Dennis Charney Ishan Paranjpe Ross O'Hagan Adam J Russak Anuradha Lala Riccardo Miotto Akhil Vaid Kipp W Johnson Matteo Danieletto Eddye Golden Dara Meyer Manbir Singh Sulaiman Somani Arjun Kapoor Sayan Manna Udit Nangia Suraj K Jaladanki Laura M Huckins Patricia Glowe Robert M Freeman Matthew A Levin Jeffrey Jhang Adolfo Firpo Joseph Finkelstein Judith A Aberg Emilia Bagiella Carol R Horowitz Barbara Murphy Jagat Narula Eric J Nestler V Fuster Carlos Cordon-Cardo Erwin P Bottinger Alexander W Charney |
| author_sort | Girish N Nadkarni |
| collection | DOAJ |
| description | Objective The COVID-19 pandemic is a global public health crisis, with over 33 million cases and 999 000 deaths worldwide. Data are needed regarding the clinical course of hospitalised patients, particularly in the USA. We aimed to compare clinical characteristic of patients with COVID-19 who had in-hospital mortality with those who were discharged alive.Design Demographic, clinical and outcomes data for patients admitted to five Mount Sinai Health System hospitals with confirmed COVID-19 between 27 February and 2 April 2020 were identified through institutional electronic health records. We performed a retrospective comparative analysis of patients who had in-hospital mortality or were discharged alive.Setting All patients were admitted to the Mount Sinai Health System, a large quaternary care urban hospital system.Participants Participants over the age of 18 years were included.Primary outcomes We investigated in-hospital mortality during the study period.Results A total of 2199 patients with COVID-19 were hospitalised during the study period. As of 2 April, 1121 (51%) patients remained hospitalised, and 1078 (49%) completed their hospital course. Of the latter, the overall mortality was 29%, and 36% required intensive care. The median age was 65 years overall and 75 years in those who died. Pre-existing conditions were present in 65% of those who died and 46% of those discharged. In those who died, the admission median lymphocyte percentage was 11.7%, D-dimer was 2.4 μg/mL, C reactive protein was 162 mg/L and procalcitonin was 0.44 ng/mL. In those discharged, the admission median lymphocyte percentage was 16.6%, D-dimer was 0.93 μg/mL, C reactive protein was 79 mg/L and procalcitonin was 0.09 ng/mL.Conclusions In our cohort of hospitalised patients, requirement of intensive care and mortality were high. Patients who died typically had more pre-existing conditions and greater perturbations in inflammatory markers as compared with those who were discharged. |
| format | Article |
| id | doaj-art-49d3bda439074873861d39f10d7bca65 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-49d3bda439074873861d39f10d7bca652025-08-20T02:07:23ZengBMJ Publishing GroupBMJ Open2044-60552020-11-01101110.1136/bmjopen-2020-040736Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York CityGirish N Nadkarni0Zahi A Fayad1Benjamin S Glicksberg2David L Reich3Prem Timsina4Arash Kia5Patricia Kovatch6Jessica K De Freitas7Paul O’Reilly8Allan Just9Dennis Charney10Ishan Paranjpe11Ross O'Hagan12Adam J Russak13Anuradha Lala14Riccardo Miotto15Akhil Vaid16Kipp W Johnson17Matteo Danieletto18Eddye Golden19Dara Meyer20Manbir Singh21Sulaiman Somani22Arjun Kapoor23Sayan Manna24Udit Nangia25Suraj K Jaladanki26Laura M Huckins27Patricia Glowe28Robert M Freeman29Matthew A Levin30Jeffrey Jhang31Adolfo Firpo32Joseph Finkelstein33Judith A Aberg34Emilia Bagiella35Carol R Horowitz36Barbara Murphy37Jagat Narula38Eric J Nestler39V Fuster40Carlos Cordon-Cardo41Erwin P Bottinger42Alexander W Charney433 Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA2 Icahn School of Medicine at Mount Sinai BioMedical Engineering and Imaging Institute, New York, New York, USADepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USAMount Sinai Data Warehouse, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USAInstitute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, New York, USAThe Office of the Dean, Icahn School of Medicine at Mount Sinai, New York, New York, USA3 Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA3 Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USAThe Zena and Michael A. Wiener Cardiovascular Institute, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USADepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USAMallinckrodt Institute Department of Radiology, Washington University in St Louis School of Medicine, St Louis, Missouri, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USADepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USADepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USADepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USADivision of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USAThe Zena and Michael A. Wiener Cardiovascular Institute, New York, New York, USADepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, USAIcahn School of Medicine at Mount Sinai Department of Medicine, New York, New York, USAIcahn School of Medicine at Mount Sinai, New York, New York, USAIcahn School of Medicine at Mount Sinai Friedman Brain Institute, New York, New York, USADepartment of Medicine, Division of Cardiology, Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA3 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USAThe Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USADepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USAObjective The COVID-19 pandemic is a global public health crisis, with over 33 million cases and 999 000 deaths worldwide. Data are needed regarding the clinical course of hospitalised patients, particularly in the USA. We aimed to compare clinical characteristic of patients with COVID-19 who had in-hospital mortality with those who were discharged alive.Design Demographic, clinical and outcomes data for patients admitted to five Mount Sinai Health System hospitals with confirmed COVID-19 between 27 February and 2 April 2020 were identified through institutional electronic health records. We performed a retrospective comparative analysis of patients who had in-hospital mortality or were discharged alive.Setting All patients were admitted to the Mount Sinai Health System, a large quaternary care urban hospital system.Participants Participants over the age of 18 years were included.Primary outcomes We investigated in-hospital mortality during the study period.Results A total of 2199 patients with COVID-19 were hospitalised during the study period. As of 2 April, 1121 (51%) patients remained hospitalised, and 1078 (49%) completed their hospital course. Of the latter, the overall mortality was 29%, and 36% required intensive care. The median age was 65 years overall and 75 years in those who died. Pre-existing conditions were present in 65% of those who died and 46% of those discharged. In those who died, the admission median lymphocyte percentage was 11.7%, D-dimer was 2.4 μg/mL, C reactive protein was 162 mg/L and procalcitonin was 0.44 ng/mL. In those discharged, the admission median lymphocyte percentage was 16.6%, D-dimer was 0.93 μg/mL, C reactive protein was 79 mg/L and procalcitonin was 0.09 ng/mL.Conclusions In our cohort of hospitalised patients, requirement of intensive care and mortality were high. Patients who died typically had more pre-existing conditions and greater perturbations in inflammatory markers as compared with those who were discharged.https://bmjopen.bmj.com/content/10/11/e040736.full |
| spellingShingle | Girish N Nadkarni Zahi A Fayad Benjamin S Glicksberg David L Reich Prem Timsina Arash Kia Patricia Kovatch Jessica K De Freitas Paul O’Reilly Allan Just Dennis Charney Ishan Paranjpe Ross O'Hagan Adam J Russak Anuradha Lala Riccardo Miotto Akhil Vaid Kipp W Johnson Matteo Danieletto Eddye Golden Dara Meyer Manbir Singh Sulaiman Somani Arjun Kapoor Sayan Manna Udit Nangia Suraj K Jaladanki Laura M Huckins Patricia Glowe Robert M Freeman Matthew A Levin Jeffrey Jhang Adolfo Firpo Joseph Finkelstein Judith A Aberg Emilia Bagiella Carol R Horowitz Barbara Murphy Jagat Narula Eric J Nestler V Fuster Carlos Cordon-Cardo Erwin P Bottinger Alexander W Charney Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City BMJ Open |
| title | Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City |
| title_full | Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City |
| title_fullStr | Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City |
| title_full_unstemmed | Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City |
| title_short | Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City |
| title_sort | retrospective cohort study of clinical characteristics of 2199 hospitalised patients with covid 19 in new york city |
| url | https://bmjopen.bmj.com/content/10/11/e040736.full |
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