THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C
The clinical and pathogenetic significance of determining HCV core-antigen (HCV core-Ag) in serum of children with hepatitis C was investigated firstly. A direct correlation between the concentration of HCV core-Ag and viral load (VL) was revealed (r = 0,91). Children with high core-Ag (above 2500 f...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Diagnostics and Vaccines"
2015-08-01
|
| Series: | Детские инфекции (Москва) |
| Subjects: | |
| Online Access: | https://detinf.elpub.ru/jour/article/view/18 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850074006355443712 |
|---|---|
| author | A. Leybman L. I. Nikolaeva G. V. Sapronov E. I. Shestakova E. I. Samokhvalov O. B. Kovalev A. G. Pisarev L. I. Konovalova A. E. Grishechkin V. F. Uchaikin |
| author_facet | A. Leybman L. I. Nikolaeva G. V. Sapronov E. I. Shestakova E. I. Samokhvalov O. B. Kovalev A. G. Pisarev L. I. Konovalova A. E. Grishechkin V. F. Uchaikin |
| author_sort | A. Leybman |
| collection | DOAJ |
| description | The clinical and pathogenetic significance of determining HCV core-antigen (HCV core-Ag) in serum of children with hepatitis C was investigated firstly. A direct correlation between the concentration of HCV core-Ag and viral load (VL) was revealed (r = 0,91). Children with high core-Ag (above 2500 fmol/L) showed indirect evidence for the immunosuppressive action of HCV core-Ag and occurrence of liver fibrosis more frequent (p < 0,05). In this grouP of children the prevalence of HCV subtype 3a was revealed (p < 0,05). |
| format | Article |
| id | doaj-art-49d1d7cb94cf4e8799f60ac0c6c2fe6e |
| institution | DOAJ |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2015-08-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-49d1d7cb94cf4e8799f60ac0c6c2fe6e2025-08-20T02:46:40ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072015-08-0113281210.22627/2072-8107-2014-13-2-8-1218THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS CA. Leybman0L. I. Nikolaeva1G. V. Sapronov2E. I. Shestakova3E. I. Samokhvalov4O. B. Kovalev5A. G. Pisarev6L. I. Konovalova7A. E. Grishechkin8V. F. Uchaikin9Russian National Research Medical University named after N. I. Pirogov, Moscow; Research Institute of Virology named after D. I. Ivanovsky, MoscowResearch Institute of Virology named after D. I. Ivanovsky, MoscowRussian Medical Academy of Post-Degree Education MoscowG. N. Speransky Children”s Hospital № 9 MoscowResearch Institute of Virology named after D. I. Ivanovsky, MoscowRussian National Research Medical University named after N. I. Pirogov, MoscowRussian National Research Medical University named after N. I. Pirogov, MoscowG. N. Speransky Children”s Hospital № 9 MoscowResearch Institute of Virology named after D. I. Ivanovsky, MoscowRussian National Research Medical University named after N. I. Pirogov, MoscowThe clinical and pathogenetic significance of determining HCV core-antigen (HCV core-Ag) in serum of children with hepatitis C was investigated firstly. A direct correlation between the concentration of HCV core-Ag and viral load (VL) was revealed (r = 0,91). Children with high core-Ag (above 2500 fmol/L) showed indirect evidence for the immunosuppressive action of HCV core-Ag and occurrence of liver fibrosis more frequent (p < 0,05). In this grouP of children the prevalence of HCV subtype 3a was revealed (p < 0,05).https://detinf.elpub.ru/jour/article/view/18chronic hepatitis cchildrenhcv core-agviral loadgenotype |
| spellingShingle | A. Leybman L. I. Nikolaeva G. V. Sapronov E. I. Shestakova E. I. Samokhvalov O. B. Kovalev A. G. Pisarev L. I. Konovalova A. E. Grishechkin V. F. Uchaikin THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C Детские инфекции (Москва) chronic hepatitis c children hcv core-ag viral load genotype |
| title | THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C |
| title_full | THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C |
| title_fullStr | THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C |
| title_full_unstemmed | THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C |
| title_short | THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C |
| title_sort | significance of quantities detection of сore antigen in blood serum of children with hepatitis c |
| topic | chronic hepatitis c children hcv core-ag viral load genotype |
| url | https://detinf.elpub.ru/jour/article/view/18 |
| work_keys_str_mv | AT aleybman thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT linikolaeva thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT gvsapronov thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT eishestakova thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT eisamokhvalov thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT obkovalev thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT agpisarev thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT likonovalova thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT aegrishechkin thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT vfuchaikin thesignificanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT aleybman significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT linikolaeva significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT gvsapronov significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT eishestakova significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT eisamokhvalov significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT obkovalev significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT agpisarev significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT likonovalova significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT aegrishechkin significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc AT vfuchaikin significanceofquantitiesdetectionofsoreantigeninbloodserumofchildrenwithhepatitisc |