THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C

THE SIGNIFICANCE OF QUANTITIES DETECTION OF СORE ANTIGEN IN BLOOD SERUM OF CHILDREN WITH HEPATITIS C

The clinical and pathogenetic significance of determining HCV core-antigen (HCV core-Ag) in serum of children with hepatitis C was investigated firstly. A direct correlation between the concentration of HCV core-Ag and viral load (VL) was revealed (r = 0,91). Children with high core-Ag (above 2500 f...

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Main Authors: A. Leybman, L. I. Nikolaeva, G. V. Sapronov, E. I. Shestakova, E. I. Samokhvalov, O. B. Kovalev, A. G. Pisarev, L. I. Konovalova, A. E. Grishechkin, V. F. Uchaikin
Format: Article
Language:Russian
Published: LLC "Diagnostics and Vaccines" 2015-08-01
Series:Детские инфекции (Москва)
Subjects:
chronic hepatitis c
children
hcv core-ag
viral load
genotype
Online Access:https://detinf.elpub.ru/jour/article/view/18
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Summary:The clinical and pathogenetic significance of determining HCV core-antigen (HCV core-Ag) in serum of children with hepatitis C was investigated firstly. A direct correlation between the concentration of HCV core-Ag and viral load (VL) was revealed (r = 0,91). Children with high core-Ag (above 2500 fmol/L) showed indirect evidence for the immunosuppressive action of HCV core-Ag and occurrence of liver fibrosis more frequent (p < 0,05). In this grouP of children the prevalence of HCV subtype 3a was revealed (p < 0,05).
ISSN:2072-8107

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