Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS
To evaluate the bioavailability of ellagic acid loaded super-saturatable self-microemulsifying drug delivery system (S-SMEDDS), its pharmacokinetic properties were studied in rats with an ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. The plasma samp...
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| Format: | Article |
| Language: | English |
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2021-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2021-0031 |
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| author | Wang Jinglong Fan Liqun Zhang Lihua Zheng Dandan Wang Yingzi Sun Xiao Ji Yonghui |
| author_facet | Wang Jinglong Fan Liqun Zhang Lihua Zheng Dandan Wang Yingzi Sun Xiao Ji Yonghui |
| author_sort | Wang Jinglong |
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| description | To evaluate the bioavailability of ellagic acid loaded super-saturatable self-microemulsifying drug delivery system (S-SMEDDS), its pharmacokinetic properties were studied in rats with an ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. The plasma samples were treated by solid-phase extraction method, and gallic acid was used as the internal standard when determining the concentration of ellagic acid. Results showed that the established analytical method was sensitive and accurate, which is applicable to the pharmacokinetic study of ellagic acid. The drug was found to be absorbed rapidly in vivo, and the plasma concentration-time curve showed double peaks, indicating that ellagic acid were reabsorbed by entero-hepatic circulation after oral administration. Compared with ellagic acid suspension, the apparent clearance of ellagic acid-loaded S-SMEDDS and SMEDDS reduced significantly, and the AUC0~t of them were 4.7 and 5.8-fold increase, respectively. Therefore, the bioavailability of ellagic acid-loaded S-SMEDDS was higher than that of the suspension and SMEDDS. |
| format | Article |
| id | doaj-art-49cf9a93a84e44f592325482374ca7e1 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-49cf9a93a84e44f592325482374ca7e12025-02-02T16:56:11ZengSciendoActa Pharmaceutica1846-95582021-12-0171467968710.2478/acph-2021-0031Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MSWang Jinglong0Fan Liqun1Zhang Lihua2Zheng Dandan3Wang Yingzi4Sun Xiao5Ji Yonghui6College of Food Sciences and Pharmaceutical Engineering, Zaozhuang University, Zaozhuang277160, ChinaCollege of Food Sciences and Pharmaceutical Engineering, Zaozhuang University, Zaozhuang277160, ChinaCollege of Food Sciences and Pharmaceutical Engineering, Zaozhuang University, Zaozhuang277160, ChinaCollege of Food Sciences and Pharmaceutical Engineering, Zaozhuang University, Zaozhuang277160, ChinaSchool of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing100029, ChinaSchool of Pharmaceutical SciencesShandong University, Jinan250012ChinaCollege of Food Sciences and Pharmaceutical Engineering, Zaozhuang University, Zaozhuang277160, ChinaTo evaluate the bioavailability of ellagic acid loaded super-saturatable self-microemulsifying drug delivery system (S-SMEDDS), its pharmacokinetic properties were studied in rats with an ultra-high performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. The plasma samples were treated by solid-phase extraction method, and gallic acid was used as the internal standard when determining the concentration of ellagic acid. Results showed that the established analytical method was sensitive and accurate, which is applicable to the pharmacokinetic study of ellagic acid. The drug was found to be absorbed rapidly in vivo, and the plasma concentration-time curve showed double peaks, indicating that ellagic acid were reabsorbed by entero-hepatic circulation after oral administration. Compared with ellagic acid suspension, the apparent clearance of ellagic acid-loaded S-SMEDDS and SMEDDS reduced significantly, and the AUC0~t of them were 4.7 and 5.8-fold increase, respectively. Therefore, the bioavailability of ellagic acid-loaded S-SMEDDS was higher than that of the suspension and SMEDDS.https://doi.org/10.2478/acph-2021-0031ellagic acidsupersaturatable self-microemulsionpharmacokineticsuhplc-q-tof-ms |
| spellingShingle | Wang Jinglong Fan Liqun Zhang Lihua Zheng Dandan Wang Yingzi Sun Xiao Ji Yonghui Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS Acta Pharmaceutica ellagic acid supersaturatable self-microemulsion pharmacokinetics uhplc-q-tof-ms |
| title | Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS |
| title_full | Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS |
| title_fullStr | Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS |
| title_full_unstemmed | Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS |
| title_short | Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS |
| title_sort | pharmacokinetics study of a supersaturatable self microemulsifying drug delivery system for ellagic acid by uhplc q tof ms |
| topic | ellagic acid supersaturatable self-microemulsion pharmacokinetics uhplc-q-tof-ms |
| url | https://doi.org/10.2478/acph-2021-0031 |
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