PPARs in the Renal Regulation of Systemic Blood Pressure
Recent research has revealed roles for the peroxisome proliferator activated receptor (PPAR) family of transcription factors in blood pressure regulation, expanding the possible therapeutic use of PPAR ligands. PPARα and PPARγ modulate the renin-angiotensin-aldosterone system (RAAS), a major regulat...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2010/698730 |
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| _version_ | 1850104134188924928 |
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| author | Tamás Rőszer Mercedes Ricote |
| author_facet | Tamás Rőszer Mercedes Ricote |
| author_sort | Tamás Rőszer |
| collection | DOAJ |
| description | Recent research has revealed roles for the peroxisome proliferator activated receptor (PPAR) family of transcription factors in blood pressure regulation, expanding the possible therapeutic use of PPAR ligands. PPARα and PPARγ modulate the renin-angiotensin-aldosterone system (RAAS), a major regulator of systemic blood pressure and interstitial fluid volume by transcriptional control of renin, angiotensinogen, angiotensin converting enzyme (ACE) and angiotensin II receptor 1 (AT-R1). Blockade of RAAS is an important therapeutic target in hypertension management and attenuates microvascular damage, glomerular inflammation and left ventricular hypertrophy in hypertensive patients and also show antidiabetic effects. The mechanisms underlying the benefits of RAAS inhibition appear to involve PPARγ-regulated pathways. This review summarizes current knowledge on the role of PPARs in the transcriptional control of the RAAS and the possible use of PPAR ligands in the treatment of RAAS dependent hypertension. |
| format | Article |
| id | doaj-art-49cbff44c1fd46b28c4325479bedf8d9 |
| institution | DOAJ |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-49cbff44c1fd46b28c4325479bedf8d92025-08-20T02:39:23ZengWileyPPAR Research1687-47571687-47652010-01-01201010.1155/2010/698730698730PPARs in the Renal Regulation of Systemic Blood PressureTamás Rőszer0Mercedes Ricote1Department of Regenerative Cardiology, Spanish National Cardiovascular Research Center (CNIC), 28029 Madrid, SpainDepartment of Regenerative Cardiology, Spanish National Cardiovascular Research Center (CNIC), 28029 Madrid, SpainRecent research has revealed roles for the peroxisome proliferator activated receptor (PPAR) family of transcription factors in blood pressure regulation, expanding the possible therapeutic use of PPAR ligands. PPARα and PPARγ modulate the renin-angiotensin-aldosterone system (RAAS), a major regulator of systemic blood pressure and interstitial fluid volume by transcriptional control of renin, angiotensinogen, angiotensin converting enzyme (ACE) and angiotensin II receptor 1 (AT-R1). Blockade of RAAS is an important therapeutic target in hypertension management and attenuates microvascular damage, glomerular inflammation and left ventricular hypertrophy in hypertensive patients and also show antidiabetic effects. The mechanisms underlying the benefits of RAAS inhibition appear to involve PPARγ-regulated pathways. This review summarizes current knowledge on the role of PPARs in the transcriptional control of the RAAS and the possible use of PPAR ligands in the treatment of RAAS dependent hypertension.http://dx.doi.org/10.1155/2010/698730 |
| spellingShingle | Tamás Rőszer Mercedes Ricote PPARs in the Renal Regulation of Systemic Blood Pressure PPAR Research |
| title | PPARs in the Renal Regulation of Systemic Blood Pressure |
| title_full | PPARs in the Renal Regulation of Systemic Blood Pressure |
| title_fullStr | PPARs in the Renal Regulation of Systemic Blood Pressure |
| title_full_unstemmed | PPARs in the Renal Regulation of Systemic Blood Pressure |
| title_short | PPARs in the Renal Regulation of Systemic Blood Pressure |
| title_sort | ppars in the renal regulation of systemic blood pressure |
| url | http://dx.doi.org/10.1155/2010/698730 |
| work_keys_str_mv | AT tamasroszer pparsintherenalregulationofsystemicbloodpressure AT mercedesricote pparsintherenalregulationofsystemicbloodpressure |