Beneficial effects of baicalein on a model of allergic rhinitis
Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo...
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| Format: | Article |
| Language: | English |
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Sciendo
2020-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2020-0009 |
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| author | Liu Tao Xu Jing Wu Yungang Li Xiaoxia Ding Detao Ma Dengdian Yao Mengwei Wei Wenzhong Zhang Wei Wang Shaohua Yao Jing Li Xiaoyu |
| author_facet | Liu Tao Xu Jing Wu Yungang Li Xiaoxia Ding Detao Ma Dengdian Yao Mengwei Wei Wenzhong Zhang Wei Wang Shaohua Yao Jing Li Xiaoyu |
| author_sort | Liu Tao |
| collection | DOAJ |
| description | Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology. |
| format | Article |
| id | doaj-art-49c8e871920b44429407fb5de12f50d7 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-49c8e871920b44429407fb5de12f50d72025-02-03T02:02:18ZengSciendoActa Pharmaceutica1846-95582020-03-01701354710.2478/acph-2020-0009acph-2020-0009Beneficial effects of baicalein on a model of allergic rhinitisLiu Tao0Xu Jing1Wu Yungang2Li Xiaoxia3Ding Detao4Ma Dengdian5Yao Mengwei6Wei Wenzhong7Zhang Wei8Wang Shaohua9Yao Jing10Li Xiaoyu11School of Clinical Medicine, Jining Medical University, Jining, Shandong, ChinaAffiliated Hospital of Jining Medical University, Jining, Shandong, ChinaAffiliated Hospital of Jining Medical University, Jining, Shandong, ChinaAffiliated Hospital of Jining Medical University, Jining, Shandong, ChinaAffiliated Hospital of Jining Medical University, Jining, Shandong, ChinaAffiliated Hospital of Jining Medical University, Jining, Shandong, ChinaAffiliated Hospital of Jining Medical University, Jining, Shandong, ChinaAffiliated Hospital of Jining Medical University, Jining, Shandong, ChinaPeople’s Hospital of Hengshui, Hengshui Hebei, ChinaAffiliated Hospital of Jining Medical University, Jining, Shandong, ChinaSchool of Basic Medicine, Jining Medical University, Jining, Shandong, ChinaSchool of Clinical Medicine, Jining Medical University, Jining, Shandong, ChinaAllergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.https://doi.org/10.2478/acph-2020-0009baicaleinovalbuminallergic rhinitisinflammatory factorsp-stat3 |
| spellingShingle | Liu Tao Xu Jing Wu Yungang Li Xiaoxia Ding Detao Ma Dengdian Yao Mengwei Wei Wenzhong Zhang Wei Wang Shaohua Yao Jing Li Xiaoyu Beneficial effects of baicalein on a model of allergic rhinitis Acta Pharmaceutica baicalein ovalbumin allergic rhinitis inflammatory factors p-stat3 |
| title | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_full | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_fullStr | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_full_unstemmed | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_short | Beneficial effects of baicalein on a model of allergic rhinitis |
| title_sort | beneficial effects of baicalein on a model of allergic rhinitis |
| topic | baicalein ovalbumin allergic rhinitis inflammatory factors p-stat3 |
| url | https://doi.org/10.2478/acph-2020-0009 |
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