Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa
This study was designed to explore the expression and the diagnostic value of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in pernicious placenta previa (PPP) combined placental accreta/increta. A total of 140 PPP patients were enrolled and divided into t...
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1999492 |
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| author | Na Wang Dandan Shi Na Li Hongyuan Qi |
| author_facet | Na Wang Dandan Shi Na Li Hongyuan Qi |
| author_sort | Na Wang |
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| description | This study was designed to explore the expression and the diagnostic value of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in pernicious placenta previa (PPP) combined placental accreta/increta. A total of 140 PPP patients were enrolled and divided into two groups: 56 patients with placenta accreta/increta (PA group), and 84 patients without placenta accreta/increta (non-PA group). In the same period, 46 pregnant women without PPP who had undergone caesarean section were selected as controls. The levels of VEGF and sFlt-1 in serum were detected by enzyme-linked immunosorbent assay. Diagnostic efficiency of VEGF and sFlt-1 in serum were evaluated by receiver operating characteristics curve. It was found that both VEGF and sFlt-1 had diagnostic value for PPP and placenta accreta/increta combined PPP. In addition, the levels of VEGF and sFlt-1 could be used to distinguish placenta accreta from placenta increta. VEGF was negatively correlated with sFlt-1 in PPP patients. In summary, the levels of VEGF and sFlt-1 could be used as auxiliary indicators to diagnose PPP and distinguish between placenta accreta and increta.KEY POINTSThe levels of VEGF and sFlt-1 could be used to distinguish placenta accreta from placenta increta.VEGF is negatively correlated with sFlt-1 in PPP patients.The levels of VEGF and sFlt-1 could be used as auxiliary indicators to diagnose PPP and distinguish between placenta accreta and increta. |
| format | Article |
| id | doaj-art-49c76eafdb5e4e7494170f22a8e5db55 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Medicine |
| spelling | doaj-art-49c76eafdb5e4e7494170f22a8e5db552025-08-20T03:43:55ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-015312041204910.1080/07853890.2021.1999492Clinical value of serum VEGF and sFlt-1 in pernicious placenta previaNa Wang0Dandan Shi1Na Li2Hongyuan Qi3Obstetrics Department, Cangzhou Central Hospital, Cangzhou, ChinaObstetrics Department, Cangzhou Central Hospital, Cangzhou, ChinaObstetrics Department, Cangzhou Central Hospital, Cangzhou, ChinaObstetrics Department, Cangzhou Central Hospital, Cangzhou, ChinaThis study was designed to explore the expression and the diagnostic value of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in pernicious placenta previa (PPP) combined placental accreta/increta. A total of 140 PPP patients were enrolled and divided into two groups: 56 patients with placenta accreta/increta (PA group), and 84 patients without placenta accreta/increta (non-PA group). In the same period, 46 pregnant women without PPP who had undergone caesarean section were selected as controls. The levels of VEGF and sFlt-1 in serum were detected by enzyme-linked immunosorbent assay. Diagnostic efficiency of VEGF and sFlt-1 in serum were evaluated by receiver operating characteristics curve. It was found that both VEGF and sFlt-1 had diagnostic value for PPP and placenta accreta/increta combined PPP. In addition, the levels of VEGF and sFlt-1 could be used to distinguish placenta accreta from placenta increta. VEGF was negatively correlated with sFlt-1 in PPP patients. In summary, the levels of VEGF and sFlt-1 could be used as auxiliary indicators to diagnose PPP and distinguish between placenta accreta and increta.KEY POINTSThe levels of VEGF and sFlt-1 could be used to distinguish placenta accreta from placenta increta.VEGF is negatively correlated with sFlt-1 in PPP patients.The levels of VEGF and sFlt-1 could be used as auxiliary indicators to diagnose PPP and distinguish between placenta accreta and increta.https://www.tandfonline.com/doi/10.1080/07853890.2021.1999492VEGFsFlt-1pernicious placenta previaplacenta accretaplacenta increta |
| spellingShingle | Na Wang Dandan Shi Na Li Hongyuan Qi Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa Annals of Medicine VEGF sFlt-1 pernicious placenta previa placenta accreta placenta increta |
| title | Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa |
| title_full | Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa |
| title_fullStr | Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa |
| title_full_unstemmed | Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa |
| title_short | Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa |
| title_sort | clinical value of serum vegf and sflt 1 in pernicious placenta previa |
| topic | VEGF sFlt-1 pernicious placenta previa placenta accreta placenta increta |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1999492 |
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