Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are emerging as key mediators of TB immunopathology and their...

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Main Authors: Catherine W M Ong, Paul T Elkington, Sara Brilha, Cesar Ugarte-Gil, Maite T Tome-Esteban, Liku B Tezera, Przemyslaw J Pabisiak, Rachel C Moores, Tarangini Sathyamoorthy, Vimal Patel, Robert H Gilman, Joanna C Porter, Jon S Friedland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004917&type=printable
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