Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study.
<h4>Background</h4>Tuberculosis (TB) substantially compromises health-related quality of life (HRQoL), yet limited studies have assessed its impact on Ethiopian patients using the EQ-5D instrument. This study evaluates HRQoL, estimates health state utility values, and identifies associat...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0326033 |
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| author | Tenaw Baye Tarekegn Getachew Alemkere Eskinder Eshetu Ali |
| author_facet | Tenaw Baye Tarekegn Getachew Alemkere Eskinder Eshetu Ali |
| author_sort | Tenaw Baye Tarekegn |
| collection | DOAJ |
| description | <h4>Background</h4>Tuberculosis (TB) substantially compromises health-related quality of life (HRQoL), yet limited studies have assessed its impact on Ethiopian patients using the EQ-5D instrument. This study evaluates HRQoL, estimates health state utility values, and identifies associated factors among TB patients in Ethiopia.<h4>Methods</h4>A cross-sectional study was conducted across 20 public health centers in Addis Ababa, Ethiopia, involving 672 TB patients selected via proportional allocation. HRQoL was measured using the EuroQol five-dimension five-level (EQ-5D-5L) tool. Predictors of utility scores were analyzed using the Kruskal-Wallis test and Tobit censored regression models.<h4>Results</h4>Anxiety/depression was the most frequently affected dimension (55.4% of participants). The mean EQ-5D-5L utility score was 0.91 (SD ± 0.14), and the mean EQ-VAS score was 80.6 (SD ± 15.6). Older age (55-64 years: β = -0.067, p < 0.001; ≥ 65 years: β = -0.383, p < 0.001) and unemployment (β = -0.119, p < 0.001) were associated with significantly lower HRQoL. Conversely, higher income (β = 0.056, p < 0.001), absence of comorbidities (β = 0.059, p < 0.001), and mid-treatment duration (4-5 months: β = 0.029, p = 0.011) correlated with better HRQoL.<h4>Conclusion</h4>The findings underscore the influence of socio-demographic and clinical factors on HRQoL among TB patients in Ethiopia, calling for targeted interventions and policy reforms to enhance treatment outcomes and patient support. |
| format | Article |
| id | doaj-art-49b8fb3b2ccd46be9d78160d182c95b4 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-49b8fb3b2ccd46be9d78160d182c95b42025-08-20T03:24:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01206e032603310.1371/journal.pone.0326033Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study.Tenaw Baye TarekegnGetachew AlemkereEskinder Eshetu Ali<h4>Background</h4>Tuberculosis (TB) substantially compromises health-related quality of life (HRQoL), yet limited studies have assessed its impact on Ethiopian patients using the EQ-5D instrument. This study evaluates HRQoL, estimates health state utility values, and identifies associated factors among TB patients in Ethiopia.<h4>Methods</h4>A cross-sectional study was conducted across 20 public health centers in Addis Ababa, Ethiopia, involving 672 TB patients selected via proportional allocation. HRQoL was measured using the EuroQol five-dimension five-level (EQ-5D-5L) tool. Predictors of utility scores were analyzed using the Kruskal-Wallis test and Tobit censored regression models.<h4>Results</h4>Anxiety/depression was the most frequently affected dimension (55.4% of participants). The mean EQ-5D-5L utility score was 0.91 (SD ± 0.14), and the mean EQ-VAS score was 80.6 (SD ± 15.6). Older age (55-64 years: β = -0.067, p < 0.001; ≥ 65 years: β = -0.383, p < 0.001) and unemployment (β = -0.119, p < 0.001) were associated with significantly lower HRQoL. Conversely, higher income (β = 0.056, p < 0.001), absence of comorbidities (β = 0.059, p < 0.001), and mid-treatment duration (4-5 months: β = 0.029, p = 0.011) correlated with better HRQoL.<h4>Conclusion</h4>The findings underscore the influence of socio-demographic and clinical factors on HRQoL among TB patients in Ethiopia, calling for targeted interventions and policy reforms to enhance treatment outcomes and patient support.https://doi.org/10.1371/journal.pone.0326033 |
| spellingShingle | Tenaw Baye Tarekegn Getachew Alemkere Eskinder Eshetu Ali Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study. PLoS ONE |
| title | Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study. |
| title_full | Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study. |
| title_fullStr | Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study. |
| title_full_unstemmed | Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study. |
| title_short | Health-Related Quality of Life measured with EQ-5D-5L among tuberculosis patients in Addis Ababa, Ethiopia: Institutional-based cross-sectional study. |
| title_sort | health related quality of life measured with eq 5d 5l among tuberculosis patients in addis ababa ethiopia institutional based cross sectional study |
| url | https://doi.org/10.1371/journal.pone.0326033 |
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